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Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus

Effect of diabetic stress and training on left ventricle MnSOD (A) and Cu/Zn SOD (B) protein content. No change in MnSOD was evident across experimental groups while both low‐ and high‐intensity exercise aerobic training led to elevations in Cu/Zn SOD when compared to control rats. Low‐intensity aerobic exercise also demonstrated significantly more Cu/Zn SOD compared to sedentary diabetic rats *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
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fig03: Effect of diabetic stress and training on left ventricle MnSOD (A) and Cu/Zn SOD (B) protein content. No change in MnSOD was evident across experimental groups while both low‐ and high‐intensity exercise aerobic training led to elevations in Cu/Zn SOD when compared to control rats. Low‐intensity aerobic exercise also demonstrated significantly more Cu/Zn SOD compared to sedentary diabetic rats *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.

Mentions: Compared to both C and CD, DH rats exhibited higher cardiac Hsp70 expression (Fig. 2; P < 0.05). Hsp70 content of both DR and DL trained rats were not significantly different from either C or CD (P > 0.05). There were no differences in MnSOD across experimental groups (Fig. 3A; P > 0.05). Compared to C, both DL and DH had significantly higher expression levels of Cu/Zn SOD, while DL had significantly elevated levels of Cu/Zn SOD in comparison to CD (Fig. 3B; P < 0.05).


Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Effect of diabetic stress and training on left ventricle MnSOD (A) and Cu/Zn SOD (B) protein content. No change in MnSOD was evident across experimental groups while both low‐ and high‐intensity exercise aerobic training led to elevations in Cu/Zn SOD when compared to control rats. Low‐intensity aerobic exercise also demonstrated significantly more Cu/Zn SOD compared to sedentary diabetic rats *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255808&req=5

fig03: Effect of diabetic stress and training on left ventricle MnSOD (A) and Cu/Zn SOD (B) protein content. No change in MnSOD was evident across experimental groups while both low‐ and high‐intensity exercise aerobic training led to elevations in Cu/Zn SOD when compared to control rats. Low‐intensity aerobic exercise also demonstrated significantly more Cu/Zn SOD compared to sedentary diabetic rats *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
Mentions: Compared to both C and CD, DH rats exhibited higher cardiac Hsp70 expression (Fig. 2; P < 0.05). Hsp70 content of both DR and DL trained rats were not significantly different from either C or CD (P > 0.05). There were no differences in MnSOD across experimental groups (Fig. 3A; P > 0.05). Compared to C, both DL and DH had significantly higher expression levels of Cu/Zn SOD, while DL had significantly elevated levels of Cu/Zn SOD in comparison to CD (Fig. 3B; P < 0.05).

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus