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Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus

Effect of T1DM and exercise training modality on left ventricle Hsp70 protein content. High‐intensity aerobic exercise training led to enhancement in Hsp70 expression in rat hearts compared to sedentary rats. *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
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fig02: Effect of T1DM and exercise training modality on left ventricle Hsp70 protein content. High‐intensity aerobic exercise training led to enhancement in Hsp70 expression in rat hearts compared to sedentary rats. *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.

Mentions: Compared to both C and CD, DH rats exhibited higher cardiac Hsp70 expression (Fig. 2; P < 0.05). Hsp70 content of both DR and DL trained rats were not significantly different from either C or CD (P > 0.05). There were no differences in MnSOD across experimental groups (Fig. 3A; P > 0.05). Compared to C, both DL and DH had significantly higher expression levels of Cu/Zn SOD, while DL had significantly elevated levels of Cu/Zn SOD in comparison to CD (Fig. 3B; P < 0.05).


Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Effect of T1DM and exercise training modality on left ventricle Hsp70 protein content. High‐intensity aerobic exercise training led to enhancement in Hsp70 expression in rat hearts compared to sedentary rats. *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255808&req=5

fig02: Effect of T1DM and exercise training modality on left ventricle Hsp70 protein content. High‐intensity aerobic exercise training led to enhancement in Hsp70 expression in rat hearts compared to sedentary rats. *different than C; †different than CD, P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
Mentions: Compared to both C and CD, DH rats exhibited higher cardiac Hsp70 expression (Fig. 2; P < 0.05). Hsp70 content of both DR and DL trained rats were not significantly different from either C or CD (P > 0.05). There were no differences in MnSOD across experimental groups (Fig. 3A; P > 0.05). Compared to C, both DL and DH had significantly higher expression levels of Cu/Zn SOD, while DL had significantly elevated levels of Cu/Zn SOD in comparison to CD (Fig. 3B; P < 0.05).

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus