Limits...
Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus

Effect of T1DM and exercise training modality on left ventricle mechanical function. The data are presented in time course format (A) and area under the curve measurement (B). Compared with control and sedentary diabetic high intensity aerobic exercise training lead to enhancement in postischemic LVDP, +dP/dt, −dP/dt and LVEDP in rat hearts following ischemic stress. *different than C; †different than CD; ‡different than DR; Ψdifferent than DH; P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4255808&req=5

fig01: Effect of T1DM and exercise training modality on left ventricle mechanical function. The data are presented in time course format (A) and area under the curve measurement (B). Compared with control and sedentary diabetic high intensity aerobic exercise training lead to enhancement in postischemic LVDP, +dP/dt, −dP/dt and LVEDP in rat hearts following ischemic stress. *different than C; †different than CD; ‡different than DR; Ψdifferent than DH; P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.

Mentions: Compared to C, diabetic groups (CD, DL, DR, and DH) demonstrated greater cardiac functional performance in postischemic left ventricular developed pressure (LVDP), maximal rate of contraction (+dP/dt), and maximal rate of relaxation (‐dP/dt) (Fig. 1; P <0.05). The demonstrated protective effects of exercise, as assessed by left ventricular performance, were not consistent across each exercise modality. DH animals showed the greatest positive benefit in cardiovascular recovery in comparison to CD and DR in all four variables examined (LVDP, LVEDP, +dP/dt, −dP/dt) (P <0.05). Both the DH and CD animals showed significantly lower left ventricular end‐diastolic pressure (LVEDP), which was not significantly different amongst the rest of the groups (P < 0.05).


Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Effect of T1DM and exercise training modality on left ventricle mechanical function. The data are presented in time course format (A) and area under the curve measurement (B). Compared with control and sedentary diabetic high intensity aerobic exercise training lead to enhancement in postischemic LVDP, +dP/dt, −dP/dt and LVEDP in rat hearts following ischemic stress. *different than C; †different than CD; ‡different than DR; Ψdifferent than DH; P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255808&req=5

fig01: Effect of T1DM and exercise training modality on left ventricle mechanical function. The data are presented in time course format (A) and area under the curve measurement (B). Compared with control and sedentary diabetic high intensity aerobic exercise training lead to enhancement in postischemic LVDP, +dP/dt, −dP/dt and LVEDP in rat hearts following ischemic stress. *different than C; †different than CD; ‡different than DR; Ψdifferent than DH; P < 0.05, based on a one‐way ANOVA. Data presented as a mean ± SE.
Mentions: Compared to C, diabetic groups (CD, DL, DR, and DH) demonstrated greater cardiac functional performance in postischemic left ventricular developed pressure (LVDP), maximal rate of contraction (+dP/dt), and maximal rate of relaxation (‐dP/dt) (Fig. 1; P <0.05). The demonstrated protective effects of exercise, as assessed by left ventricular performance, were not consistent across each exercise modality. DH animals showed the greatest positive benefit in cardiovascular recovery in comparison to CD and DR in all four variables examined (LVDP, LVEDP, +dP/dt, −dP/dt) (P <0.05). Both the DH and CD animals showed significantly lower left ventricular end‐diastolic pressure (LVEDP), which was not significantly different amongst the rest of the groups (P < 0.05).

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus