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Characterization of acute ischemia-related physiological responses associated with remote ischemic preconditioning: a randomized controlled, crossover human study.

Sharma V, Cunniffe B, Verma AP, Cardinale M, Yellon D - Physiol Rep (2014)

Bottom Line: There is little evidence to support what limb (upper or lower) or cuff inflation pressures are most effective to deliver this intervention without causing undue discomfort/pain in nonanesthetized humans.Physiological changes in the occluded limb and any pain/discomfort associated with RIPC with each cuff inflation pressure were determined.However, whether benefits of RIPC can also be derived with protocols delivered to the upper limb using lower cuff inflation pressures and with lesser discomfort compared to the lower limb, remains to be investigated.

View Article: PubMed Central - PubMed

Affiliation: The Hatter Cardiovascular Institute, UCL, London, UK Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA.

No MeSH data available.


Related in: MedlinePlus

Significant rise (from baseline) in pCO2 is noted with cuff inflation in the upper limb at all pressures (P <0.01). For lower limb, values reach significance at 180 mmHg cuff inflation pressure only.
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fig04: Significant rise (from baseline) in pCO2 is noted with cuff inflation in the upper limb at all pressures (P <0.01). For lower limb, values reach significance at 180 mmHg cuff inflation pressure only.

Mentions: In the upper limb, significant increases were noted in the pCO2 levels at all the cuff inflation pressures assessed (Table 2; Fig. 4). At 140 mmHg, there was a significant increase in the capillary blood pCO2 levels in the upper limb at the end of the second and the third cuff inflation only. At 160 and 180 mmHg cuff inflation pressures (UL), a significant increase in the pCO2 levels was observed in all cycles of RIPC (P < 0.01). At the end of 5 min of the cuff deflation, pCO2 levels returned back to baseline with the exception of the third cuff inflation at 180 mmHg, where 10‐min recovery time was required before pCO2 levels returned to baseline. In comparison, no significant changes were noted in the pCO2 levels at 140 and 160 mmHg cuff inflations, in the lower limb. At 180 mmHg there was a progressive rise in pCO2 levels with successive cuff inflations, values reaching significance during the second and third cuff inflation (P < 0.01). In the lower limb, the pCO2 levels recovered back to the baseline at the end of 5 min of cuff deflation. Significant effects were observed for “inflation pressure” and “limb” for pCO2 levels (P = 0.0003). In the upper limb, all three cuff inflation pressures led to significant increase in the mean pCO2 levels recorded at the end of 5 min of cuff inflation, while conversely, only the highest cuff inflation pressure was able to induce significant increase in capillary arterial levels of pCO2 in the lower limb.


Characterization of acute ischemia-related physiological responses associated with remote ischemic preconditioning: a randomized controlled, crossover human study.

Sharma V, Cunniffe B, Verma AP, Cardinale M, Yellon D - Physiol Rep (2014)

Significant rise (from baseline) in pCO2 is noted with cuff inflation in the upper limb at all pressures (P <0.01). For lower limb, values reach significance at 180 mmHg cuff inflation pressure only.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255807&req=5

fig04: Significant rise (from baseline) in pCO2 is noted with cuff inflation in the upper limb at all pressures (P <0.01). For lower limb, values reach significance at 180 mmHg cuff inflation pressure only.
Mentions: In the upper limb, significant increases were noted in the pCO2 levels at all the cuff inflation pressures assessed (Table 2; Fig. 4). At 140 mmHg, there was a significant increase in the capillary blood pCO2 levels in the upper limb at the end of the second and the third cuff inflation only. At 160 and 180 mmHg cuff inflation pressures (UL), a significant increase in the pCO2 levels was observed in all cycles of RIPC (P < 0.01). At the end of 5 min of the cuff deflation, pCO2 levels returned back to baseline with the exception of the third cuff inflation at 180 mmHg, where 10‐min recovery time was required before pCO2 levels returned to baseline. In comparison, no significant changes were noted in the pCO2 levels at 140 and 160 mmHg cuff inflations, in the lower limb. At 180 mmHg there was a progressive rise in pCO2 levels with successive cuff inflations, values reaching significance during the second and third cuff inflation (P < 0.01). In the lower limb, the pCO2 levels recovered back to the baseline at the end of 5 min of cuff deflation. Significant effects were observed for “inflation pressure” and “limb” for pCO2 levels (P = 0.0003). In the upper limb, all three cuff inflation pressures led to significant increase in the mean pCO2 levels recorded at the end of 5 min of cuff inflation, while conversely, only the highest cuff inflation pressure was able to induce significant increase in capillary arterial levels of pCO2 in the lower limb.

Bottom Line: There is little evidence to support what limb (upper or lower) or cuff inflation pressures are most effective to deliver this intervention without causing undue discomfort/pain in nonanesthetized humans.Physiological changes in the occluded limb and any pain/discomfort associated with RIPC with each cuff inflation pressure were determined.However, whether benefits of RIPC can also be derived with protocols delivered to the upper limb using lower cuff inflation pressures and with lesser discomfort compared to the lower limb, remains to be investigated.

View Article: PubMed Central - PubMed

Affiliation: The Hatter Cardiovascular Institute, UCL, London, UK Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA.

No MeSH data available.


Related in: MedlinePlus