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Characterization of acute ischemia-related physiological responses associated with remote ischemic preconditioning: a randomized controlled, crossover human study.

Sharma V, Cunniffe B, Verma AP, Cardinale M, Yellon D - Physiol Rep (2014)

Bottom Line: There is little evidence to support what limb (upper or lower) or cuff inflation pressures are most effective to deliver this intervention without causing undue discomfort/pain in nonanesthetized humans.Physiological changes in the occluded limb and any pain/discomfort associated with RIPC with each cuff inflation pressure were determined.However, whether benefits of RIPC can also be derived with protocols delivered to the upper limb using lower cuff inflation pressures and with lesser discomfort compared to the lower limb, remains to be investigated.

View Article: PubMed Central - PubMed

Affiliation: The Hatter Cardiovascular Institute, UCL, London, UK Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA.

No MeSH data available.


Related in: MedlinePlus

Changes in the capillary blood oxygen saturation with varying cuff inflation pressures per limb. While significant changes were noted in the mean capillary oxygen saturation levels at all cuff inflation pressures applied to the upper limb, in the lower limb only the highest cuff inflation pressure used (180 mmHg) led to significant changes.
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fig03: Changes in the capillary blood oxygen saturation with varying cuff inflation pressures per limb. While significant changes were noted in the mean capillary oxygen saturation levels at all cuff inflation pressures applied to the upper limb, in the lower limb only the highest cuff inflation pressure used (180 mmHg) led to significant changes.

Mentions: A significant reduction was noted in the mean sO2 (%) in the upper limb with each of the three cuff inflations during all three cycles of RIPC at all the cuff inflation pressures (140, 160, and 180 mmHg) (P < 0.01). In the lower limb, only the highest cuff inflation pressure of 180 mmHg led to a significant reduction in the mean sO2 (%) level in the limb compared with the baseline (Table 2; Fig. 3). In all the cases where there was a significant reduction in sO2 during cuff inflation, the mean sO2 (%) levels returned back to baseline after 5 min of reperfusion of the limb after the cuff was deflated. Similarly, significant reduction in the pO2 was noted with each cuff inflation during the three cycles of RIPC at each of the three cuff inflation pressures (140, 160, and 180 mmHg) in the upper limb (P < 0.01) (Table 2). In the lower limb only the higher cuff inflation pressure of 180 mmHg was able to cause a significant reduction in the pO2 levels. After 5 min of reperfusion of the limb with the cuff deflated, the pO2 levels returned back to the baseline in all cases. These changes in sO2 and pO2 over the duration of the three cycles of RIPC varied significantly based on the cuff inflation pressure and limb used (P < 0.01). While there were comparable significant changes in sO2 and pO2 levels in both the upper and lower limbs with cuff inflation at 180 mmHg pressure, cuff inflation at lower pressures of 140 and 160 mmHg led to significant changes in the upper limb but not in the lower limb.


Characterization of acute ischemia-related physiological responses associated with remote ischemic preconditioning: a randomized controlled, crossover human study.

Sharma V, Cunniffe B, Verma AP, Cardinale M, Yellon D - Physiol Rep (2014)

Changes in the capillary blood oxygen saturation with varying cuff inflation pressures per limb. While significant changes were noted in the mean capillary oxygen saturation levels at all cuff inflation pressures applied to the upper limb, in the lower limb only the highest cuff inflation pressure used (180 mmHg) led to significant changes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255807&req=5

fig03: Changes in the capillary blood oxygen saturation with varying cuff inflation pressures per limb. While significant changes were noted in the mean capillary oxygen saturation levels at all cuff inflation pressures applied to the upper limb, in the lower limb only the highest cuff inflation pressure used (180 mmHg) led to significant changes.
Mentions: A significant reduction was noted in the mean sO2 (%) in the upper limb with each of the three cuff inflations during all three cycles of RIPC at all the cuff inflation pressures (140, 160, and 180 mmHg) (P < 0.01). In the lower limb, only the highest cuff inflation pressure of 180 mmHg led to a significant reduction in the mean sO2 (%) level in the limb compared with the baseline (Table 2; Fig. 3). In all the cases where there was a significant reduction in sO2 during cuff inflation, the mean sO2 (%) levels returned back to baseline after 5 min of reperfusion of the limb after the cuff was deflated. Similarly, significant reduction in the pO2 was noted with each cuff inflation during the three cycles of RIPC at each of the three cuff inflation pressures (140, 160, and 180 mmHg) in the upper limb (P < 0.01) (Table 2). In the lower limb only the higher cuff inflation pressure of 180 mmHg was able to cause a significant reduction in the pO2 levels. After 5 min of reperfusion of the limb with the cuff deflated, the pO2 levels returned back to the baseline in all cases. These changes in sO2 and pO2 over the duration of the three cycles of RIPC varied significantly based on the cuff inflation pressure and limb used (P < 0.01). While there were comparable significant changes in sO2 and pO2 levels in both the upper and lower limbs with cuff inflation at 180 mmHg pressure, cuff inflation at lower pressures of 140 and 160 mmHg led to significant changes in the upper limb but not in the lower limb.

Bottom Line: There is little evidence to support what limb (upper or lower) or cuff inflation pressures are most effective to deliver this intervention without causing undue discomfort/pain in nonanesthetized humans.Physiological changes in the occluded limb and any pain/discomfort associated with RIPC with each cuff inflation pressure were determined.However, whether benefits of RIPC can also be derived with protocols delivered to the upper limb using lower cuff inflation pressures and with lesser discomfort compared to the lower limb, remains to be investigated.

View Article: PubMed Central - PubMed

Affiliation: The Hatter Cardiovascular Institute, UCL, London, UK Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA.

No MeSH data available.


Related in: MedlinePlus