Limits...
Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation.

Shen Q, Holloway N, Thimmesch A, Wood JG, Clancy RL, Pierce JD - Physiol Rep (2014)

Bottom Line: In addition, vascular permeability in the control group (0.54 ± 0.11) was significantly greater than the ubiquinol group (0.34 ± 0.04).In conclusion, ubiquinol attenuates HS and FR-induced microvascular inflammation.These results suggest that ubiquinol provides protection to mesenteric microcirculation through its antioxidant properties.

View Article: PubMed Central - PubMed

Affiliation: School of Nursing, University of Kansas, Kansas City, Kansas, USA (Q.S., A.T., J.D.P.).

No MeSH data available.


Related in: MedlinePlus

Reactive oxygen species (ROS) levels in the mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups following hemorrhagic shock (HS) and fluid resuscitation (FR). Dihydrorhodamine (DHR) fluorescence intensity was used to determine ROS levels. Values of DHR fluorescence intensity at HS and every 30 min post FR were expressed relative to baseline value (100%). †Significantly different from baseline (P <0.01). *Significantly different from the control group (P <0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4255806&req=5

fig04: Reactive oxygen species (ROS) levels in the mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups following hemorrhagic shock (HS) and fluid resuscitation (FR). Dihydrorhodamine (DHR) fluorescence intensity was used to determine ROS levels. Values of DHR fluorescence intensity at HS and every 30 min post FR were expressed relative to baseline value (100%). †Significantly different from baseline (P <0.01). *Significantly different from the control group (P <0.05).

Mentions: The cumulative data of ROS levels estimated by DHR fluorescence intensity at baseline, HS, 30‐min, 60‐min, 90‐min, and 120‐min after FR in the control and ubiquinol groups are displayed in Figure 4. The DHR fluorescence intensities at HS and every 30 min after FR were expressed relative to baseline value (100%). The ROS levels in the control group significantly increased compared to baseline following FR (P < 0.01). The ROS levels in the ubiquinol group at 2 h after FR also significantly increased to 159 ± 35% of baseline (P <0.01); however, it was significantly less than the control group (343 ± 47%) (P < 0.01).


Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation.

Shen Q, Holloway N, Thimmesch A, Wood JG, Clancy RL, Pierce JD - Physiol Rep (2014)

Reactive oxygen species (ROS) levels in the mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups following hemorrhagic shock (HS) and fluid resuscitation (FR). Dihydrorhodamine (DHR) fluorescence intensity was used to determine ROS levels. Values of DHR fluorescence intensity at HS and every 30 min post FR were expressed relative to baseline value (100%). †Significantly different from baseline (P <0.01). *Significantly different from the control group (P <0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255806&req=5

fig04: Reactive oxygen species (ROS) levels in the mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups following hemorrhagic shock (HS) and fluid resuscitation (FR). Dihydrorhodamine (DHR) fluorescence intensity was used to determine ROS levels. Values of DHR fluorescence intensity at HS and every 30 min post FR were expressed relative to baseline value (100%). †Significantly different from baseline (P <0.01). *Significantly different from the control group (P <0.05).
Mentions: The cumulative data of ROS levels estimated by DHR fluorescence intensity at baseline, HS, 30‐min, 60‐min, 90‐min, and 120‐min after FR in the control and ubiquinol groups are displayed in Figure 4. The DHR fluorescence intensities at HS and every 30 min after FR were expressed relative to baseline value (100%). The ROS levels in the control group significantly increased compared to baseline following FR (P < 0.01). The ROS levels in the ubiquinol group at 2 h after FR also significantly increased to 159 ± 35% of baseline (P <0.01); however, it was significantly less than the control group (343 ± 47%) (P < 0.01).

Bottom Line: In addition, vascular permeability in the control group (0.54 ± 0.11) was significantly greater than the ubiquinol group (0.34 ± 0.04).In conclusion, ubiquinol attenuates HS and FR-induced microvascular inflammation.These results suggest that ubiquinol provides protection to mesenteric microcirculation through its antioxidant properties.

View Article: PubMed Central - PubMed

Affiliation: School of Nursing, University of Kansas, Kansas City, Kansas, USA (Q.S., A.T., J.D.P.).

No MeSH data available.


Related in: MedlinePlus