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Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation.

Shen Q, Holloway N, Thimmesch A, Wood JG, Clancy RL, Pierce JD - Physiol Rep (2014)

Bottom Line: In addition, vascular permeability in the control group (0.54 ± 0.11) was significantly greater than the ubiquinol group (0.34 ± 0.04).In conclusion, ubiquinol attenuates HS and FR-induced microvascular inflammation.These results suggest that ubiquinol provides protection to mesenteric microcirculation through its antioxidant properties.

View Article: PubMed Central - PubMed

Affiliation: School of Nursing, University of Kansas, Kansas City, Kansas, USA (Q.S., A.T., J.D.P.).

No MeSH data available.


Related in: MedlinePlus

Number of adherent leukocytes per 100 μm of mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups at baseline, during hemorrhagic shock (HS), and fluid resuscitation (FR). †Significantly different from baseline (P < 0.05). *Significantly different from the control group (P <0.01).
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fig02: Number of adherent leukocytes per 100 μm of mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups at baseline, during hemorrhagic shock (HS), and fluid resuscitation (FR). †Significantly different from baseline (P < 0.05). *Significantly different from the control group (P <0.01).

Mentions: Figure 1 illustrates exemplar images of leukocyte adherence in the mesenteric venules 2‐h post FR in a control rat and an ubiquinol rat. Less than two adherent leukocytes were observed during the 30‐min control period in both groups. The time course of leukocyte adherence is presented in Figure 2. A modest but insignificant increase in the number of adherent leukocytes during HS occurred in both groups. Beginning at 40 min of FR, the number of adherent leukocytes in the control group rapidly increased, reaching almost 10 times the baseline value at the end of the experiment. In contrast, leukocyte adherence in the ubiquinol group remained at baseline level throughout the FR period. The average venular diameter in the ubiquinol group was 27 ± 2 μm, which was not significantly different from that in the control group (23 ± 1 μm). In addition, the differences in shear rates for the control and ubiquinol groups were not statistically significant at baseline (747 ± 96 vs. 445 ± 117), HS (775 ± 99 vs. 554 ± 172), and FR (745 ± 103 vs. 462 ± 109).


Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation.

Shen Q, Holloway N, Thimmesch A, Wood JG, Clancy RL, Pierce JD - Physiol Rep (2014)

Number of adherent leukocytes per 100 μm of mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups at baseline, during hemorrhagic shock (HS), and fluid resuscitation (FR). †Significantly different from baseline (P < 0.05). *Significantly different from the control group (P <0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255806&req=5

fig02: Number of adherent leukocytes per 100 μm of mesenteric venule in the control (n = 6) and ubiquinol (n = 6) groups at baseline, during hemorrhagic shock (HS), and fluid resuscitation (FR). †Significantly different from baseline (P < 0.05). *Significantly different from the control group (P <0.01).
Mentions: Figure 1 illustrates exemplar images of leukocyte adherence in the mesenteric venules 2‐h post FR in a control rat and an ubiquinol rat. Less than two adherent leukocytes were observed during the 30‐min control period in both groups. The time course of leukocyte adherence is presented in Figure 2. A modest but insignificant increase in the number of adherent leukocytes during HS occurred in both groups. Beginning at 40 min of FR, the number of adherent leukocytes in the control group rapidly increased, reaching almost 10 times the baseline value at the end of the experiment. In contrast, leukocyte adherence in the ubiquinol group remained at baseline level throughout the FR period. The average venular diameter in the ubiquinol group was 27 ± 2 μm, which was not significantly different from that in the control group (23 ± 1 μm). In addition, the differences in shear rates for the control and ubiquinol groups were not statistically significant at baseline (747 ± 96 vs. 445 ± 117), HS (775 ± 99 vs. 554 ± 172), and FR (745 ± 103 vs. 462 ± 109).

Bottom Line: In addition, vascular permeability in the control group (0.54 ± 0.11) was significantly greater than the ubiquinol group (0.34 ± 0.04).In conclusion, ubiquinol attenuates HS and FR-induced microvascular inflammation.These results suggest that ubiquinol provides protection to mesenteric microcirculation through its antioxidant properties.

View Article: PubMed Central - PubMed

Affiliation: School of Nursing, University of Kansas, Kansas City, Kansas, USA (Q.S., A.T., J.D.P.).

No MeSH data available.


Related in: MedlinePlus