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Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention.

Li Y, Lee S, Langleite T, Norheim F, Pourteymour S, Jensen J, Stadheim HK, Storås TH, Davanger S, Gulseth HL, Birkeland KI, Drevon CA, Holen T - Physiol Rep (2014)

Bottom Line: Lipid droplet volume in the subsarcolemmal LD population was reduced by ~80%, in both groups, while IMF LD volume was unchanged.Our results show that the SS LD lipid store was sensitive to training, whereas the dominant IMF LD lipid store was not.Thus, net muscle lipid stores can be an insufficient measure for the effects of training.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Institute of Basic Medical Science, University of Oslo, Oslo, Norway.

No MeSH data available.


Related in: MedlinePlus

Lipid droplet (LD) numbers in subsarcolemmal (SS) and intramyofibrillar (IMF) regions before and after the 12‐week exercise intervention. (A) Electron micrographs of SS and IMF LD. Scale bar is 1 μm. (B) LD density in SS region. Left panel: dysglycemic group subjects. Right panel: control group subjects. (C) LD density in IMF region. Left panel: Dysglycemic group subjects. Right panel: Control group subjects.
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fig01: Lipid droplet (LD) numbers in subsarcolemmal (SS) and intramyofibrillar (IMF) regions before and after the 12‐week exercise intervention. (A) Electron micrographs of SS and IMF LD. Scale bar is 1 μm. (B) LD density in SS region. Left panel: dysglycemic group subjects. Right panel: control group subjects. (C) LD density in IMF region. Left panel: Dysglycemic group subjects. Right panel: Control group subjects.

Mentions: In order to study the basic characteristics of muscle LD and the effect of the training intervention, we performed an extensive, blinded, randomized study of 1440 EM images from the SS and IMF regions (Fig. 1A). In total, 14 505 LD were directly counted for density measurements, and of these, 10 958 LD diameters were measured.


Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention.

Li Y, Lee S, Langleite T, Norheim F, Pourteymour S, Jensen J, Stadheim HK, Storås TH, Davanger S, Gulseth HL, Birkeland KI, Drevon CA, Holen T - Physiol Rep (2014)

Lipid droplet (LD) numbers in subsarcolemmal (SS) and intramyofibrillar (IMF) regions before and after the 12‐week exercise intervention. (A) Electron micrographs of SS and IMF LD. Scale bar is 1 μm. (B) LD density in SS region. Left panel: dysglycemic group subjects. Right panel: control group subjects. (C) LD density in IMF region. Left panel: Dysglycemic group subjects. Right panel: Control group subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255802&req=5

fig01: Lipid droplet (LD) numbers in subsarcolemmal (SS) and intramyofibrillar (IMF) regions before and after the 12‐week exercise intervention. (A) Electron micrographs of SS and IMF LD. Scale bar is 1 μm. (B) LD density in SS region. Left panel: dysglycemic group subjects. Right panel: control group subjects. (C) LD density in IMF region. Left panel: Dysglycemic group subjects. Right panel: Control group subjects.
Mentions: In order to study the basic characteristics of muscle LD and the effect of the training intervention, we performed an extensive, blinded, randomized study of 1440 EM images from the SS and IMF regions (Fig. 1A). In total, 14 505 LD were directly counted for density measurements, and of these, 10 958 LD diameters were measured.

Bottom Line: Lipid droplet volume in the subsarcolemmal LD population was reduced by ~80%, in both groups, while IMF LD volume was unchanged.Our results show that the SS LD lipid store was sensitive to training, whereas the dominant IMF LD lipid store was not.Thus, net muscle lipid stores can be an insufficient measure for the effects of training.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Institute of Basic Medical Science, University of Oslo, Oslo, Norway.

No MeSH data available.


Related in: MedlinePlus