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Stand-up exercise training facilitates muscle recovery from disuse atrophy by stimulating myogenic satellite cell proliferation in mice.

Itoh Y, Hayakawa K, Mori T, Agata N, Inoue-Miyazu M, Murakami T, Sokabe M, Kawakami K - Physiol Rep (2014)

Bottom Line: Seven days after the training, average myofiber cross-sectional area (CSA) of the soleus muscle was significantly greater in the SE-trained group than in the non-SE-trained group (1843 ± 194 μm(2) vs. 1315 ± 153 μm(2)).Mean soleus muscle CSA in the SE trained group was not different from that in the CON group subjected to neither TS nor SE training (2005 ± 196 μm(2)), indicating that SE training caused nearly complete recovery from muscle atrophy.The number of myonuclei per myofiber was increased by ~60% in the SE-trained group compared with the non-SE-trained and CON groups (0.92 ± 0.03 vs. 0.57 ± 0.03 and 0.56 ± 0.11, respectively).

View Article: PubMed Central - PubMed

Affiliation: Physical and Occupational Therapy Program, Nagoya University Graduate School of Medicine, Nagoya, Japan Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan.

No MeSH data available.


Related in: MedlinePlus

Changes in muscle histology after prolonged tail suspension (TS). (A) Whole‐muscle cross‐sectional area (CSA), (B) myofiber CSA, and (C) the number of myofibers after hind limb unloading using prolonged TS. Whole‐muscle CSA, myofiber CSA, and the number of myofibers were significantly reduced in the TS group compared with the control non‐TS group. Solid bars, TS group; open bars, non‐TS group. Results are means ± SEM's; n = 6 per group. *P <0.05.
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fig02: Changes in muscle histology after prolonged tail suspension (TS). (A) Whole‐muscle cross‐sectional area (CSA), (B) myofiber CSA, and (C) the number of myofibers after hind limb unloading using prolonged TS. Whole‐muscle CSA, myofiber CSA, and the number of myofibers were significantly reduced in the TS group compared with the control non‐TS group. Solid bars, TS group; open bars, non‐TS group. Results are means ± SEM's; n = 6 per group. *P <0.05.

Mentions: We first assessed the histological changes in mouse soleus muscles after 14 days of TS (Fig. 1A). Whole‐soleus muscle CSA was significantly reduced in the TS group compared with that in the non‐TS control group (Fig. 2A). The mean myofiber CSA was also significantly smaller in the TS group compared with that in the non‐TS group (Fig. 2B), as were the numbers of myofibers per muscle (Fig. 2C). Thus, TS had resulted in significant soleus muscle atrophy.


Stand-up exercise training facilitates muscle recovery from disuse atrophy by stimulating myogenic satellite cell proliferation in mice.

Itoh Y, Hayakawa K, Mori T, Agata N, Inoue-Miyazu M, Murakami T, Sokabe M, Kawakami K - Physiol Rep (2014)

Changes in muscle histology after prolonged tail suspension (TS). (A) Whole‐muscle cross‐sectional area (CSA), (B) myofiber CSA, and (C) the number of myofibers after hind limb unloading using prolonged TS. Whole‐muscle CSA, myofiber CSA, and the number of myofibers were significantly reduced in the TS group compared with the control non‐TS group. Solid bars, TS group; open bars, non‐TS group. Results are means ± SEM's; n = 6 per group. *P <0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255801&req=5

fig02: Changes in muscle histology after prolonged tail suspension (TS). (A) Whole‐muscle cross‐sectional area (CSA), (B) myofiber CSA, and (C) the number of myofibers after hind limb unloading using prolonged TS. Whole‐muscle CSA, myofiber CSA, and the number of myofibers were significantly reduced in the TS group compared with the control non‐TS group. Solid bars, TS group; open bars, non‐TS group. Results are means ± SEM's; n = 6 per group. *P <0.05.
Mentions: We first assessed the histological changes in mouse soleus muscles after 14 days of TS (Fig. 1A). Whole‐soleus muscle CSA was significantly reduced in the TS group compared with that in the non‐TS control group (Fig. 2A). The mean myofiber CSA was also significantly smaller in the TS group compared with that in the non‐TS group (Fig. 2B), as were the numbers of myofibers per muscle (Fig. 2C). Thus, TS had resulted in significant soleus muscle atrophy.

Bottom Line: Seven days after the training, average myofiber cross-sectional area (CSA) of the soleus muscle was significantly greater in the SE-trained group than in the non-SE-trained group (1843 ± 194 μm(2) vs. 1315 ± 153 μm(2)).Mean soleus muscle CSA in the SE trained group was not different from that in the CON group subjected to neither TS nor SE training (2005 ± 196 μm(2)), indicating that SE training caused nearly complete recovery from muscle atrophy.The number of myonuclei per myofiber was increased by ~60% in the SE-trained group compared with the non-SE-trained and CON groups (0.92 ± 0.03 vs. 0.57 ± 0.03 and 0.56 ± 0.11, respectively).

View Article: PubMed Central - PubMed

Affiliation: Physical and Occupational Therapy Program, Nagoya University Graduate School of Medicine, Nagoya, Japan Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan.

No MeSH data available.


Related in: MedlinePlus