Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.
Bottom Line: However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.Clusters of subgenotype B2 and C2 consisted of strains from China and other East Asian countries, while subgenotype C1, C5, and C7 and genotype I formed a cluster together with strains from Southeast Asia.
Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.Show MeSH
Related in: MedlinePlus
Mentions: Through Bayesian evolutionary calculation, the mean value of the evolutionary rate of HBV/B pre-S/S fragment was estimated as 3.26 × 10−4 substitutions/site/year (95% HPD, 7.50 × 10−5–5.61 × 10−4). Based on sequences of these strains and other reference strains from other regions, the time-scaled Bayesian tree was reconstructed (Fig. 3A). As the most prevalent subgenotype, most of the strains of subgenotype B2 were intermixed with the other reference strains, but a small significant clad including five strains were distinct. The estimated timing of tree's root suggested that genotype B was originated in the 1860s. Whereas, several significant clades in subgenotype B2 from Yunnan were dated back to 37 years ago, corresponding to the later of 1970s.
Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.