Limits...
Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.

Wang B, Feng Y, Li Z, Duan H, Zhao T, Zhang A, Liu L, Baloch Z, Xia X - J. Med. Virol. (2014)

Bottom Line: Hepatitis B virus (HBV) is one of the most prevalent pathogens in the world, and infection with this virus is a serious threat for public health.However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Show MeSH

Related in: MedlinePlus

Phylogenetic analysis (A) and SimPlot bootstrap analysis (B) on nucleotide sequence of YN.071 with consensus sequences representing each of the genotypes A–I. YN.071 had high similarity with genotype D from 1 to 745 nt and high similarity with genotype C from 746 to 3,215 nt.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4255792&req=5

fig02: Phylogenetic analysis (A) and SimPlot bootstrap analysis (B) on nucleotide sequence of YN.071 with consensus sequences representing each of the genotypes A–I. YN.071 had high similarity with genotype D from 1 to 745 nt and high similarity with genotype C from 746 to 3,215 nt.

Mentions: The reconstructed neighbor-joining tree also showed that the strains of subgenotype B2 and C2, which were identified as the most prevalent subgenotypes in Yunnan, were mixed together with strains from China and other East Asian countries in their respective clusters. The strains of subgenotype C1, C5, and C7 forming a cluster closely with the strains from Southeast Asia, suggests a close genetic relationship between them. Two strains of genotype I being grouped together with Vietnamese strains in the same branch, indicates that they probably originated from Vietnam. The bootstrap value between sample YN.071 recombinant and C/D1 recombinant from western China was 99%. To confirm further the recombinant nature of YN.071, phylogenetic and bootscan analyses on the sequence of complete genomes were performed. The inter-genotypes recombinant model was verified in the reach of full-length sequences. The breakpoint of C/D1 recombinant (Fig. 2) was similar to that of previous reported recombinants [Wang et al., 2005; Zhou et al., 2011].


Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.

Wang B, Feng Y, Li Z, Duan H, Zhao T, Zhang A, Liu L, Baloch Z, Xia X - J. Med. Virol. (2014)

Phylogenetic analysis (A) and SimPlot bootstrap analysis (B) on nucleotide sequence of YN.071 with consensus sequences representing each of the genotypes A–I. YN.071 had high similarity with genotype D from 1 to 745 nt and high similarity with genotype C from 746 to 3,215 nt.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255792&req=5

fig02: Phylogenetic analysis (A) and SimPlot bootstrap analysis (B) on nucleotide sequence of YN.071 with consensus sequences representing each of the genotypes A–I. YN.071 had high similarity with genotype D from 1 to 745 nt and high similarity with genotype C from 746 to 3,215 nt.
Mentions: The reconstructed neighbor-joining tree also showed that the strains of subgenotype B2 and C2, which were identified as the most prevalent subgenotypes in Yunnan, were mixed together with strains from China and other East Asian countries in their respective clusters. The strains of subgenotype C1, C5, and C7 forming a cluster closely with the strains from Southeast Asia, suggests a close genetic relationship between them. Two strains of genotype I being grouped together with Vietnamese strains in the same branch, indicates that they probably originated from Vietnam. The bootstrap value between sample YN.071 recombinant and C/D1 recombinant from western China was 99%. To confirm further the recombinant nature of YN.071, phylogenetic and bootscan analyses on the sequence of complete genomes were performed. The inter-genotypes recombinant model was verified in the reach of full-length sequences. The breakpoint of C/D1 recombinant (Fig. 2) was similar to that of previous reported recombinants [Wang et al., 2005; Zhou et al., 2011].

Bottom Line: Hepatitis B virus (HBV) is one of the most prevalent pathogens in the world, and infection with this virus is a serious threat for public health.However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Show MeSH
Related in: MedlinePlus