Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.
Bottom Line: However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.Clusters of subgenotype B2 and C2 consisted of strains from China and other East Asian countries, while subgenotype C1, C5, and C7 and genotype I formed a cluster together with strains from Southeast Asia.
Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.Show MeSH
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Mentions: The reconstructed neighbor-joining tree also showed that the strains of subgenotype B2 and C2, which were identified as the most prevalent subgenotypes in Yunnan, were mixed together with strains from China and other East Asian countries in their respective clusters. The strains of subgenotype C1, C5, and C7 forming a cluster closely with the strains from Southeast Asia, suggests a close genetic relationship between them. Two strains of genotype I being grouped together with Vietnamese strains in the same branch, indicates that they probably originated from Vietnam. The bootstrap value between sample YN.071 recombinant and C/D1 recombinant from western China was 99%. To confirm further the recombinant nature of YN.071, phylogenetic and bootscan analyses on the sequence of complete genomes were performed. The inter-genotypes recombinant model was verified in the reach of full-length sequences. The breakpoint of C/D1 recombinant (Fig. 2) was similar to that of previous reported recombinants [Wang et al., 2005; Zhou et al., 2011].
Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.