Limits...
Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.

Wang B, Feng Y, Li Z, Duan H, Zhao T, Zhang A, Liu L, Baloch Z, Xia X - J. Med. Virol. (2014)

Bottom Line: Hepatitis B virus (HBV) is one of the most prevalent pathogens in the world, and infection with this virus is a serious threat for public health.However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Show MeSH

Related in: MedlinePlus

Phylogenetic analysis of pre-S/S sequences of HBV strain in Yunnan compared with reference strains representing genotypes A–I. Accession numbers and countries are shown in each branch, and HBV genotypes or subgenotypes are listed on the right. Bootstrap values were shown along each main branch. The characterized strains in this study are marked with black dots.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4255792&req=5

fig01: Phylogenetic analysis of pre-S/S sequences of HBV strain in Yunnan compared with reference strains representing genotypes A–I. Accession numbers and countries are shown in each branch, and HBV genotypes or subgenotypes are listed on the right. Bootstrap values were shown along each main branch. The characterized strains in this study are marked with black dots.

Mentions: The HBV genotype could be determined by phylogenetic analysis in 72 patients. It accounts for four HBV genotypes (B, C, C/D, and I) identified in this study. Among them, genotype C was the most prevalent with infection of 45 (62.5%) patients, followed by genotype B (24/72, 33.3%) and genotype I (2/72, 2.78%). According to their phylogenetic relationship, HBV genotype B consisted of a single subgenotype B2, while HBV genotype C could be classified into several subgenotypes including 28 cases of C2, 10 cases of C1, 3 cases of C5, and 4 cases of C7 (Fig. 1). Notably, subgenotype C1, C5, and C7 were most prevalent among the ethnic population of Southeast Asia. Sample YN.071, collected at Qujing, the most northeastern prefecture in Yunnan, was clustered as a C/D1 recombinant together with two strains from western China. In comparing with other genotypes, higher level of liver function parameters were observed in genotype C, but not significant (dates not shown).


Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.

Wang B, Feng Y, Li Z, Duan H, Zhao T, Zhang A, Liu L, Baloch Z, Xia X - J. Med. Virol. (2014)

Phylogenetic analysis of pre-S/S sequences of HBV strain in Yunnan compared with reference strains representing genotypes A–I. Accession numbers and countries are shown in each branch, and HBV genotypes or subgenotypes are listed on the right. Bootstrap values were shown along each main branch. The characterized strains in this study are marked with black dots.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255792&req=5

fig01: Phylogenetic analysis of pre-S/S sequences of HBV strain in Yunnan compared with reference strains representing genotypes A–I. Accession numbers and countries are shown in each branch, and HBV genotypes or subgenotypes are listed on the right. Bootstrap values were shown along each main branch. The characterized strains in this study are marked with black dots.
Mentions: The HBV genotype could be determined by phylogenetic analysis in 72 patients. It accounts for four HBV genotypes (B, C, C/D, and I) identified in this study. Among them, genotype C was the most prevalent with infection of 45 (62.5%) patients, followed by genotype B (24/72, 33.3%) and genotype I (2/72, 2.78%). According to their phylogenetic relationship, HBV genotype B consisted of a single subgenotype B2, while HBV genotype C could be classified into several subgenotypes including 28 cases of C2, 10 cases of C1, 3 cases of C5, and 4 cases of C7 (Fig. 1). Notably, subgenotype C1, C5, and C7 were most prevalent among the ethnic population of Southeast Asia. Sample YN.071, collected at Qujing, the most northeastern prefecture in Yunnan, was clustered as a C/D1 recombinant together with two strains from western China. In comparing with other genotypes, higher level of liver function parameters were observed in genotype C, but not significant (dates not shown).

Bottom Line: Hepatitis B virus (HBV) is one of the most prevalent pathogens in the world, and infection with this virus is a serious threat for public health.However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Show MeSH
Related in: MedlinePlus