Distribution and diversity of hepatitis B virus genotypes in Yunnan, China.
Bottom Line: Hepatitis B virus (HBV) is one of the most prevalent pathogens in the world, and infection with this virus is a serious threat for public health.However, the distribution and diversity of HBV subgenotypes remain unclear in Yunnan province.In the current study, HBV positive samples were collected from different prefectures of Yunnan province and their molecular epidemiological characters were determined.
Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.Show MeSH
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Mentions: The HBV genotype could be determined by phylogenetic analysis in 72 patients. It accounts for four HBV genotypes (B, C, C/D, and I) identified in this study. Among them, genotype C was the most prevalent with infection of 45 (62.5%) patients, followed by genotype B (24/72, 33.3%) and genotype I (2/72, 2.78%). According to their phylogenetic relationship, HBV genotype B consisted of a single subgenotype B2, while HBV genotype C could be classified into several subgenotypes including 28 cases of C2, 10 cases of C1, 3 cases of C5, and 4 cases of C7 (Fig. 1). Notably, subgenotype C1, C5, and C7 were most prevalent among the ethnic population of Southeast Asia. Sample YN.071, collected at Qujing, the most northeastern prefecture in Yunnan, was clustered as a C/D1 recombinant together with two strains from western China. In comparing with other genotypes, higher level of liver function parameters were observed in genotype C, but not significant (dates not shown).
Affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.