Efficacy of the melanocortin analogue Nle4-D-Phe7-α-melanocyte-stimulating hormone in the treatment of patients with Hailey-Hailey disease.
Bottom Line: Our results show that Nrf2 is an important target of the afamelanotide signalling that reduces oxidative stress.Because afamelanotide possesses antioxidant effects, we also assessed the clinical potential of this α-MSH analogue in the treatment of patients with HHD.Afamelanotide is effective for the treatment of skin lesions in HHD.
Affiliation: Porphyria Center, San Gallicano Institute IRCCS, Rome, Italy.Show MeSH
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Mentions: Real-time RT-PCR analysis showed that Nrf2 mRNA was significantly downregulated in keratinocytes derived from cutaneous lesions of patients with HHD (Fig.1a). These results were confirmed by the western blotting of keratinocyte lysates from patients 1 and 2 (Fig.1b).
Affiliation: Porphyria Center, San Gallicano Institute IRCCS, Rome, Italy.