Albuminoid genes: evolving at the interface of dispensability and selection.
Bottom Line: Population genetic analysis revealed that GC was also the target of locally exerted selective pressure, which drove the frequency increase of different haplotypes in distinct human populations.A search for known variants that modulate GC and 25-hydroxyvitamin D concentrations revealed linkage disequilibrium with positively selected variants, although European and Asian major GC haplotypes carry alleles with reported opposite effect on GC concentration.Data herein indicate that albumin, an extremely abundant housekeeping protein, was the target of pervasive and episodic selection in mammals, whereas GC represented a selection target during the recent evolution of human populations.
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy email@example.com.Show MeSH
Mentions: In YRI one variant (rs17766549) at high DAF (0.98) was an FST outlier in the YRI/CEU comparison, and also displayed an unusually high DIND value (table 4). These results were confirmed by the DH analysis (fig. 4A): The variant fell in a local valley of DH, in line with this statistic having maximum power for high-frequency sweeps (Zeng et al. 2006) (table 4). Overall, these results indicate that a selective sweep drove the frequency increase of this variant in YRI. The SNP is located in a region where enhancer- and promoter-associated histone marks are located, as assessed by ENCODE data (fig. 4A).Fig. 4.—
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy firstname.lastname@example.org.