Albuminoid genes: evolving at the interface of dispensability and selection.
Bottom Line: Application of a population genetics-phylogenetics approach showed that purifying selection represented a major force acting on albuminoid genes in both humans and chimpanzees, with the strongest constraint observed for human GC.Population genetic analysis revealed that GC was also the target of locally exerted selective pressure, which drove the frequency increase of different haplotypes in distinct human populations.Data herein indicate that albumin, an extremely abundant housekeeping protein, was the target of pervasive and episodic selection in mammals, whereas GC represented a selection target during the recent evolution of human populations.
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy firstname.lastname@example.org.Show MeSH
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Mentions: In both humans and chimpanzees, we observed a general preponderance of codons evolving under negative selection (γ < 0) in all genes. The most striking difference was observed for GC, which showed stronger purifying selection compared with the other three genes in humans but not in chimpanzees (fig. 3A).Fig. 3.—
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy email@example.com.