Albuminoid genes: evolving at the interface of dispensability and selection.
Bottom Line: Population genetic analysis revealed that GC was also the target of locally exerted selective pressure, which drove the frequency increase of different haplotypes in distinct human populations.A search for known variants that modulate GC and 25-hydroxyvitamin D concentrations revealed linkage disequilibrium with positively selected variants, although European and Asian major GC haplotypes carry alleles with reported opposite effect on GC concentration.Data herein indicate that albumin, an extremely abundant housekeeping protein, was the target of pervasive and episodic selection in mammals, whereas GC represented a selection target during the recent evolution of human populations.
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy email@example.com.Show MeSH
Mentions: Albumin presents a modular structural organization composed of three homologous helical domains (I, II, and III) arranged in a heart-shaped molecule. Each domain comprises two separated subdomains (A and B), containing six and four helices, respectively. Available crystallographic data revealed binding sites for fatty acids (Bhattacharya et al. 2000), hemin, bilirubin (Zunszain et al. 2003, 2008), thyroxine hormone (Petitpas et al. 2003), prostaglandins (Yamaguchi et al. 2010), and a wide variety of chemical drugs (Curry 2009) (fig. 2A).Fig. 2.—
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy firstname.lastname@example.org.