Albuminoid genes: evolving at the interface of dispensability and selection.
Bottom Line: Application of a population genetics-phylogenetics approach showed that purifying selection represented a major force acting on albuminoid genes in both humans and chimpanzees, with the strongest constraint observed for human GC.Population genetic analysis revealed that GC was also the target of locally exerted selective pressure, which drove the frequency increase of different haplotypes in distinct human populations.Data herein indicate that albumin, an extremely abundant housekeeping protein, was the target of pervasive and episodic selection in mammals, whereas GC represented a selection target during the recent evolution of human populations.
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy firstname.lastname@example.org.Show MeSH
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Mentions: Albumin presents a modular structural organization composed of three homologous helical domains (I, II, and III) arranged in a heart-shaped molecule. Each domain comprises two separated subdomains (A and B), containing six and four helices, respectively. Available crystallographic data revealed binding sites for fatty acids (Bhattacharya et al. 2000), hemin, bilirubin (Zunszain et al. 2003, 2008), thyroxine hormone (Petitpas et al. 2003), prostaglandins (Yamaguchi et al. 2010), and a wide variety of chemical drugs (Curry 2009) (fig. 2A).Fig. 2.—
Affiliation: Bioinformatics, Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Italy email@example.com.