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The effect of evening primrose oil for the prevention of xerotic cheilitis in acne patients being treated with isotretinoin: a pilot study.

Park KY, Ko EJ, Kim IS, Li K, Kim BJ, Seo SJ, Kim MN, Hong CK - Ann Dermatol (2014)

Bottom Line: The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients.The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change.The increase of the TEWL of the lip was more definite in the control group than in the experimental group.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

ABSTRACT

Background: The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients.

Objective: To evaluate the clinical efficacy and safety of EPO in preventing xerotic cheilitis in acne patients being treated with oral isotretinoin.

Methods: Forty Korean volunteers of Fitzpatrick skin types III and IV, having moderate acne, were enrolled and randomized to receive either isotretinoin with or without EPO for 8 weeks. The efficacy of treatment was evaluated on the basis of global acne grading system scores, number of inflammatory and noninflammatory lesions, TEWL, corneometry, physician's global assessment, and patient satisfaction.

Results: The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change. The increase of the TEWL of the lip was more definite in the control group than in the experimental group. The number of acne lesions decreased significantly in both groups, and there were no differences between them.

Conclusion: Our study suggests that the addition of EPO improved xerotic cheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments, additional studies are required for a complete understanding of the role of EPO in xerotic cheilitis in acne patients being treated with oral isotretinoin.

No MeSH data available.


Related in: MedlinePlus

(A) On the lower lip, the experimental group tended to have a lower score than the control group for transepidermal water loss (TEWL), and there was a significant difference between the two groups after 8 weeks of treatment. (B) Corneometry showed no significant differences between the two groups. EPO: evening primrose oil.
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Figure 2: (A) On the lower lip, the experimental group tended to have a lower score than the control group for transepidermal water loss (TEWL), and there was a significant difference between the two groups after 8 weeks of treatment. (B) Corneometry showed no significant differences between the two groups. EPO: evening primrose oil.

Mentions: The clinical evaluation of the other cutaneous symptoms except xerotic cheilitis did not differ significantly between groups, although the experimental group tended to have a lower score than the control group for dryness of the skin (Fig. 1, Table 3, 4). The proportion of patients presenting with xerotic cheilitis after 2 months of therapy was significantly lower in the experimental group. On the lower lip, the experimental group tended to have a lower score than the control group for TEWL, and there was a significant difference between the two groups after 8 weeks of treatment (Fig. 2A, Table 5). Corneometry showed no significant differences between the two groups (Fig. 2B, Table 6).


The effect of evening primrose oil for the prevention of xerotic cheilitis in acne patients being treated with isotretinoin: a pilot study.

Park KY, Ko EJ, Kim IS, Li K, Kim BJ, Seo SJ, Kim MN, Hong CK - Ann Dermatol (2014)

(A) On the lower lip, the experimental group tended to have a lower score than the control group for transepidermal water loss (TEWL), and there was a significant difference between the two groups after 8 weeks of treatment. (B) Corneometry showed no significant differences between the two groups. EPO: evening primrose oil.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4252667&req=5

Figure 2: (A) On the lower lip, the experimental group tended to have a lower score than the control group for transepidermal water loss (TEWL), and there was a significant difference between the two groups after 8 weeks of treatment. (B) Corneometry showed no significant differences between the two groups. EPO: evening primrose oil.
Mentions: The clinical evaluation of the other cutaneous symptoms except xerotic cheilitis did not differ significantly between groups, although the experimental group tended to have a lower score than the control group for dryness of the skin (Fig. 1, Table 3, 4). The proportion of patients presenting with xerotic cheilitis after 2 months of therapy was significantly lower in the experimental group. On the lower lip, the experimental group tended to have a lower score than the control group for TEWL, and there was a significant difference between the two groups after 8 weeks of treatment (Fig. 2A, Table 5). Corneometry showed no significant differences between the two groups (Fig. 2B, Table 6).

Bottom Line: The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients.The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change.The increase of the TEWL of the lip was more definite in the control group than in the experimental group.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

ABSTRACT

Background: The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients.

Objective: To evaluate the clinical efficacy and safety of EPO in preventing xerotic cheilitis in acne patients being treated with oral isotretinoin.

Methods: Forty Korean volunteers of Fitzpatrick skin types III and IV, having moderate acne, were enrolled and randomized to receive either isotretinoin with or without EPO for 8 weeks. The efficacy of treatment was evaluated on the basis of global acne grading system scores, number of inflammatory and noninflammatory lesions, TEWL, corneometry, physician's global assessment, and patient satisfaction.

Results: The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change. The increase of the TEWL of the lip was more definite in the control group than in the experimental group. The number of acne lesions decreased significantly in both groups, and there were no differences between them.

Conclusion: Our study suggests that the addition of EPO improved xerotic cheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments, additional studies are required for a complete understanding of the role of EPO in xerotic cheilitis in acne patients being treated with oral isotretinoin.

No MeSH data available.


Related in: MedlinePlus