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Annular lesions located on the right forearm.

Pileri A, Tengattini V, Bardazzi F, Misciali C, Patrizi A - Indian J Dermatol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Specialized, Diagnostic and Experimental Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.

AUTOMATICALLY GENERATED EXCERPT
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Notably, the patient had been affected by multiple myeloma (MM) immunoglobulin G (IgG)/lambda (stage IA) since 2005, in complete remission for 3 years... Physical examination revealed erythematous, nonscaling lesions set on the right forearm measuring from 1 to 4 cm [Figure 1]... The patient did not complain any itch from the lesions nor reported any previous intake of drugs... In the meantime, the patient suffered an MM relapse and a cycle of melphalan chlorhydrate and prednisone was started... Furthermore, GA can precede or follow internal malignancies such as breast or colon carcinomas, Hodgkin and non-Hodgkin lymphoma, and leukemia (acute myelogenous leukemia, large granular lymphocytic leukmia)... Patients are commonly older than 60 years... The disease can often improve if the concomitant malignancy is successfully treated... GA eruption presented when MM began relapsing after 3 years of complete remission... However, the relapse was observed 3 years after the eruption... This finding corroborates with the experiences of Hinckley et al., and Vestey et al., with four GA cases characterized by an underlying myelodysplastic syndrome... In particular, two patients presented an acute myeloid leukemia... To our knowledge, we report for the first time a case of MM presenting a GA eruption... This case leaves open the question whether GA eruption should be considered as a paraneoplastic lesion, both in terms of predicting and as sign of clinical worsening.

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Related in: MedlinePlus

Histopathology of lesion showing area of degenerated collagen, lymphohistiocytic infiltrate, mucin deposition, and giant cells (H and E, ×40).
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Figure 2: Histopathology of lesion showing area of degenerated collagen, lymphohistiocytic infiltrate, mucin deposition, and giant cells (H and E, ×40).

Mentions: The patient did not complain any itch from the lesions nor reported any previous intake of drugs. A punch biopsy revealed a lymphohistiocytic infiltrate, degenerated collagen, and mucin deposition [Figure 2].


Annular lesions located on the right forearm.

Pileri A, Tengattini V, Bardazzi F, Misciali C, Patrizi A - Indian J Dermatol (2014)

Histopathology of lesion showing area of degenerated collagen, lymphohistiocytic infiltrate, mucin deposition, and giant cells (H and E, ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248552&req=5

Figure 2: Histopathology of lesion showing area of degenerated collagen, lymphohistiocytic infiltrate, mucin deposition, and giant cells (H and E, ×40).
Mentions: The patient did not complain any itch from the lesions nor reported any previous intake of drugs. A punch biopsy revealed a lymphohistiocytic infiltrate, degenerated collagen, and mucin deposition [Figure 2].

View Article: PubMed Central - PubMed

Affiliation: Department of Specialized, Diagnostic and Experimental Medicine, Division of Dermatology, University of Bologna, Bologna, Italy.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Notably, the patient had been affected by multiple myeloma (MM) immunoglobulin G (IgG)/lambda (stage IA) since 2005, in complete remission for 3 years... Physical examination revealed erythematous, nonscaling lesions set on the right forearm measuring from 1 to 4 cm [Figure 1]... The patient did not complain any itch from the lesions nor reported any previous intake of drugs... In the meantime, the patient suffered an MM relapse and a cycle of melphalan chlorhydrate and prednisone was started... Furthermore, GA can precede or follow internal malignancies such as breast or colon carcinomas, Hodgkin and non-Hodgkin lymphoma, and leukemia (acute myelogenous leukemia, large granular lymphocytic leukmia)... Patients are commonly older than 60 years... The disease can often improve if the concomitant malignancy is successfully treated... GA eruption presented when MM began relapsing after 3 years of complete remission... However, the relapse was observed 3 years after the eruption... This finding corroborates with the experiences of Hinckley et al., and Vestey et al., with four GA cases characterized by an underlying myelodysplastic syndrome... In particular, two patients presented an acute myeloid leukemia... To our knowledge, we report for the first time a case of MM presenting a GA eruption... This case leaves open the question whether GA eruption should be considered as a paraneoplastic lesion, both in terms of predicting and as sign of clinical worsening.

No MeSH data available.


Related in: MedlinePlus