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Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant.

Pai K, Shetty S, Padmapriya J, Pai S, Rao L - Indian J Dermatol (2014)

Bottom Line: The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma.Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease.We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Kasturba Medical College, KMC International Center, Manipal University, Manipal, Karnataka, India.

ABSTRACT
Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease. We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

No MeSH data available.


Related in: MedlinePlus

(a) Photomicrograph showing full thickness dysplasia of the epidermis, H and E, ×100. (b) Showing nuclear pleomorphism with altered polarity, increased mitosis and apoptosis, H and E, ×200
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Figure 2: (a) Photomicrograph showing full thickness dysplasia of the epidermis, H and E, ×100. (b) Showing nuclear pleomorphism with altered polarity, increased mitosis and apoptosis, H and E, ×200

Mentions: Histopathological examination of the incisional biopsy from the lesion showed entire thickness of the epithelium exhibiting atypical keratinocytes with altered polarity, exhibiting marked nuclear pleomorphism, hyperchromasia and increased number of atypical mitosis [Figure 2a and b]. Also seen was intra-epidermal bulla/cleft formation in the suprabasal location and the presence of acantholytic anaplastic keratinocytes within the bulla [Figure 3]. A diagnosis of Bowen's disease-acantholytic variant (squamous cell carcinoma in-situ) was made and a wide excision of the lesion was advised.


Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant.

Pai K, Shetty S, Padmapriya J, Pai S, Rao L - Indian J Dermatol (2014)

(a) Photomicrograph showing full thickness dysplasia of the epidermis, H and E, ×100. (b) Showing nuclear pleomorphism with altered polarity, increased mitosis and apoptosis, H and E, ×200
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248544&req=5

Figure 2: (a) Photomicrograph showing full thickness dysplasia of the epidermis, H and E, ×100. (b) Showing nuclear pleomorphism with altered polarity, increased mitosis and apoptosis, H and E, ×200
Mentions: Histopathological examination of the incisional biopsy from the lesion showed entire thickness of the epithelium exhibiting atypical keratinocytes with altered polarity, exhibiting marked nuclear pleomorphism, hyperchromasia and increased number of atypical mitosis [Figure 2a and b]. Also seen was intra-epidermal bulla/cleft formation in the suprabasal location and the presence of acantholytic anaplastic keratinocytes within the bulla [Figure 3]. A diagnosis of Bowen's disease-acantholytic variant (squamous cell carcinoma in-situ) was made and a wide excision of the lesion was advised.

Bottom Line: The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma.Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease.We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Kasturba Medical College, KMC International Center, Manipal University, Manipal, Karnataka, India.

ABSTRACT
Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease. We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

No MeSH data available.


Related in: MedlinePlus