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Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant.

Pai K, Shetty S, Padmapriya J, Pai S, Rao L - Indian J Dermatol (2014)

Bottom Line: The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma.Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease.We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Kasturba Medical College, KMC International Center, Manipal University, Manipal, Karnataka, India.

ABSTRACT
Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease. We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

No MeSH data available.


Related in: MedlinePlus

Clinical picture showing large erythematous, crusted plaque on the forearm
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Figure 1: Clinical picture showing large erythematous, crusted plaque on the forearm

Mentions: A 44-year-old Indian male presented with a 2-year history of gradually enlarging pigmented skin lesion of his left arm with occasional itching. Physical examination revealed slightly elevated hyperpigmented plaque measuring 6 × 4 cms with well-defined borders and mild scaling over the lateral aspect of his left arm [Figure 1]. There was no associated lymphadenopathy. Patient had used treatment with topical corticosteroids and salicylic acid preparations without relief. An incisional biopsy was taken with a clinical differential diagnosis of Bowen's disease, localized psoriasis, and lupus vulgaris.


Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant.

Pai K, Shetty S, Padmapriya J, Pai S, Rao L - Indian J Dermatol (2014)

Clinical picture showing large erythematous, crusted plaque on the forearm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248544&req=5

Figure 1: Clinical picture showing large erythematous, crusted plaque on the forearm
Mentions: A 44-year-old Indian male presented with a 2-year history of gradually enlarging pigmented skin lesion of his left arm with occasional itching. Physical examination revealed slightly elevated hyperpigmented plaque measuring 6 × 4 cms with well-defined borders and mild scaling over the lateral aspect of his left arm [Figure 1]. There was no associated lymphadenopathy. Patient had used treatment with topical corticosteroids and salicylic acid preparations without relief. An incisional biopsy was taken with a clinical differential diagnosis of Bowen's disease, localized psoriasis, and lupus vulgaris.

Bottom Line: The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma.Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease.We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Kasturba Medical College, KMC International Center, Manipal University, Manipal, Karnataka, India.

ABSTRACT
Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease. We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.

No MeSH data available.


Related in: MedlinePlus