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Multiple hamartoma syndrome: clinicoradiological evaluation and histopathological correlation with brief review of literature.

Monga E, Gupta PK, Munshi A, Agarwal S - Indian J Dermatol (2014)

Bottom Line: Cowden syndrome (CS) or multiple hamartoma syndromes (MHSs) is an uncommon condition and characterized by mucocutaneous lesions which may be associated with the lesions of breast, thyroid, gastrointestinal tract, skin, and often of central nervous system.We are reporting a case of female patient who presented with multiple mucocutaneous papilloma associated with involvement of multiple organs and systems.Being a rare case, we are discussing MHS with its clinicoradiological and histopathological correlation along with brief review of literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Imaging and Interventional Radiology, N.S.C.B. Subharti Medical College, Swami Vivekananda Subharti University, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.

ABSTRACT
Cowden syndrome (CS) or multiple hamartoma syndromes (MHSs) is an uncommon condition and characterized by mucocutaneous lesions which may be associated with the lesions of breast, thyroid, gastrointestinal tract, skin, and often of central nervous system. A thorough evaluation of Cowden's disease is essential due to increased risk of malignancy in an organ or system of the affected patients. We are reporting a case of female patient who presented with multiple mucocutaneous papilloma associated with involvement of multiple organs and systems. The diagnosis was confirmed by multimodality diagnostic approach. This rare entity has not being reviewed in Indian literature till date. Being a rare case, we are discussing MHS with its clinicoradiological and histopathological correlation along with brief review of literature.

No MeSH data available.


Related in: MedlinePlus

Barium examination shows polyps in stomach and colon
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Figure 7: Barium examination shows polyps in stomach and colon

Mentions: Barium studies showed multiple sessile, smoothly outlined polyps in the body of stomach, antrum, and jejunal regions. Few polyps were also seen in colon [Figure 7]. These were confirmed by upper G.I. endoscopy and colonoscopy. Endoscopy showed multiple polypoid lesions with smooth overlying mucosal surface. These nodules were hyperplastic, sessile, and adenomatous fibroid type. All these lesions were 2-5 mm in size in upper G.I. region and 2-8 mm in colonic region [Figure 8].


Multiple hamartoma syndrome: clinicoradiological evaluation and histopathological correlation with brief review of literature.

Monga E, Gupta PK, Munshi A, Agarwal S - Indian J Dermatol (2014)

Barium examination shows polyps in stomach and colon
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248500&req=5

Figure 7: Barium examination shows polyps in stomach and colon
Mentions: Barium studies showed multiple sessile, smoothly outlined polyps in the body of stomach, antrum, and jejunal regions. Few polyps were also seen in colon [Figure 7]. These were confirmed by upper G.I. endoscopy and colonoscopy. Endoscopy showed multiple polypoid lesions with smooth overlying mucosal surface. These nodules were hyperplastic, sessile, and adenomatous fibroid type. All these lesions were 2-5 mm in size in upper G.I. region and 2-8 mm in colonic region [Figure 8].

Bottom Line: Cowden syndrome (CS) or multiple hamartoma syndromes (MHSs) is an uncommon condition and characterized by mucocutaneous lesions which may be associated with the lesions of breast, thyroid, gastrointestinal tract, skin, and often of central nervous system.We are reporting a case of female patient who presented with multiple mucocutaneous papilloma associated with involvement of multiple organs and systems.Being a rare case, we are discussing MHS with its clinicoradiological and histopathological correlation along with brief review of literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Imaging and Interventional Radiology, N.S.C.B. Subharti Medical College, Swami Vivekananda Subharti University, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.

ABSTRACT
Cowden syndrome (CS) or multiple hamartoma syndromes (MHSs) is an uncommon condition and characterized by mucocutaneous lesions which may be associated with the lesions of breast, thyroid, gastrointestinal tract, skin, and often of central nervous system. A thorough evaluation of Cowden's disease is essential due to increased risk of malignancy in an organ or system of the affected patients. We are reporting a case of female patient who presented with multiple mucocutaneous papilloma associated with involvement of multiple organs and systems. The diagnosis was confirmed by multimodality diagnostic approach. This rare entity has not being reviewed in Indian literature till date. Being a rare case, we are discussing MHS with its clinicoradiological and histopathological correlation along with brief review of literature.

No MeSH data available.


Related in: MedlinePlus