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Glycine gated spiking inhibitory postsynaptic membrane at the synaptic cleft.

Deka KM, Roy S - Ann Neurosci (2014)

Bottom Line: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.Simulation is performed in MATLAB environment for inhibitory action of synapses.This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

View Article: PubMed Central - PubMed

Affiliation: Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.

ABSTRACT

Background: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.

Purpose: The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glycine gated ion channels of postsynaptic membrane at the synaptic cleft.

Methods: In this paper, Glycine sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.

Results: Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for inhibitory action of synapses.

Conclusion: This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

No MeSH data available.


Electrical equivalent circuit of synapse.
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fig_2: Electrical equivalent circuit of synapse.

Mentions: The electrical mechanism of synapse is shown in Figure 1. If the synapse is excitatory, Sodium ions flow into the cell resulting into positive current. As a result the membrane depolarizes. If sufficient number of Sodium channels open, then membrane potential will be greater than the threshold potential VT of the neuron and initiates an action potential. If the synapse is inhibitory, chloride ions move into the cell, resulting into negative current. As a result the membrane hyperpolarizes. If the numbers of opening of Chloride channels are sufficiently large then membrane potential will be able to initiate an action potential in negative direction. Figure 2 shows the equivalent circuit of a synapse which is developed by adding Hodgkin-Huxley(H-H) equivalent circuit with the presynaptic circuit, where I is the total current from ionic channels of all synapses and E1, E2, …., EM represent the chemical potentials of each corresponding ions. For example, EM may be ENa or may be ECl. The total current I will stimulate the postsynaptic neuron to initiate an action potential.9–12


Glycine gated spiking inhibitory postsynaptic membrane at the synaptic cleft.

Deka KM, Roy S - Ann Neurosci (2014)

Electrical equivalent circuit of synapse.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248464&req=5

fig_2: Electrical equivalent circuit of synapse.
Mentions: The electrical mechanism of synapse is shown in Figure 1. If the synapse is excitatory, Sodium ions flow into the cell resulting into positive current. As a result the membrane depolarizes. If sufficient number of Sodium channels open, then membrane potential will be greater than the threshold potential VT of the neuron and initiates an action potential. If the synapse is inhibitory, chloride ions move into the cell, resulting into negative current. As a result the membrane hyperpolarizes. If the numbers of opening of Chloride channels are sufficiently large then membrane potential will be able to initiate an action potential in negative direction. Figure 2 shows the equivalent circuit of a synapse which is developed by adding Hodgkin-Huxley(H-H) equivalent circuit with the presynaptic circuit, where I is the total current from ionic channels of all synapses and E1, E2, …., EM represent the chemical potentials of each corresponding ions. For example, EM may be ENa or may be ECl. The total current I will stimulate the postsynaptic neuron to initiate an action potential.9–12

Bottom Line: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.Simulation is performed in MATLAB environment for inhibitory action of synapses.This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

View Article: PubMed Central - PubMed

Affiliation: Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.

ABSTRACT

Background: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.

Purpose: The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glycine gated ion channels of postsynaptic membrane at the synaptic cleft.

Methods: In this paper, Glycine sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.

Results: Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for inhibitory action of synapses.

Conclusion: This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

No MeSH data available.