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Glycine gated spiking inhibitory postsynaptic membrane at the synaptic cleft.

Deka KM, Roy S - Ann Neurosci (2014)

Bottom Line: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.Simulation is performed in MATLAB environment for inhibitory action of synapses.This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

View Article: PubMed Central - PubMed

Affiliation: Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.

ABSTRACT

Background: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.

Purpose: The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glycine gated ion channels of postsynaptic membrane at the synaptic cleft.

Methods: In this paper, Glycine sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.

Results: Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for inhibitory action of synapses.

Conclusion: This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

No MeSH data available.


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Glycine gated spiking inhibitory postsynaptic membrane at the synaptic cleft.

Deka KM, Roy S - Ann Neurosci (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248464&req=5

Bottom Line: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.Simulation is performed in MATLAB environment for inhibitory action of synapses.This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

View Article: PubMed Central - PubMed

Affiliation: Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.

ABSTRACT

Background: Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.

Purpose: The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glycine gated ion channels of postsynaptic membrane at the synaptic cleft.

Methods: In this paper, Glycine sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.

Results: Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for inhibitory action of synapses.

Conclusion: This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

No MeSH data available.