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Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.

Cao YW, Li WQ, Wan GX, Li YX, Du XM, Li YC, Li F - J. Exp. Clin. Cancer Res. (2014)

Bottom Line: The three markers significantly correlated with lymph node status.Patients with low SIRT1 expression exhibited shorter overall survival (OS) and disease-free survival (DFS), and patients with combined low expression of SIRT1 and high expression of N1IC had the worse OS and DFS.Univariate and multivariate survival analysis revealed that low expression of SIRT1 and SIRT1-low/N1IC-high expression were independent prognostic factors for poor survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, 832000, China. cywwb2013@126.com.

ABSTRACT

Background: SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined. The purpose of this study was to assess the possible prognostic value of SIRT1, N1IC, and Snail expression in breast cancer patients.

Methods: Immunohistochemistry was performed to examine the expression of SIRT1, N1IC, and Snail, and the combined expression of SIRT1 and N1IC, using tissue microarrays containing breast cancer tissue and matched adjacent normal breast tissue from 150 breast cancer patients. Survival analysis was carried out using the Kaplan-Meier method. Univariate and multivariate analysis were used to evaluate the prognostic value of SIRT1, N1IC, Snail and combined SIRT1/N1IC expression, in addition to other clinicopathological factors, including grade, lymph node status, disease stage, and estrogen, progesterone, and human epidermal growth factor receptor 2 receptor status in breast carcinoma patients.

Results: SIRT1, N1IC, and Snail were all found to be highly expressed and an inverse correlation between SIRT1 and N1IC in breast cancer tissue. The three markers significantly correlated with lymph node status. Patients with low SIRT1 expression exhibited shorter overall survival (OS) and disease-free survival (DFS), and patients with combined low expression of SIRT1 and high expression of N1IC had the worse OS and DFS. Univariate and multivariate survival analysis revealed that low expression of SIRT1 and SIRT1-low/N1IC-high expression were independent prognostic factors for poor survival.

Conclusions: These results suggest that low expression of SIRT1 or the combined low expression of SIRT1 and high expression of N1IC could be used as indicators of poor prognosis, and may represent novel therapeutic targets in breast cancer.

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Related in: MedlinePlus

Survival analyses for SIRT1, N1IC and Snail expression in breast cancer patients. A) Association of expression level of SIRT1 with OS and DFS. B) Association of expression level of N1IC with OS and DFS. C) Association of expression level of Snail with OS and DFS. D) Association of combined expression status of SIRT1 and N1IC with OS and DFS. E) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-low with OS and DFS. F) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-high with OS and DFS.
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Fig4: Survival analyses for SIRT1, N1IC and Snail expression in breast cancer patients. A) Association of expression level of SIRT1 with OS and DFS. B) Association of expression level of N1IC with OS and DFS. C) Association of expression level of Snail with OS and DFS. D) Association of combined expression status of SIRT1 and N1IC with OS and DFS. E) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-low with OS and DFS. F) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-high with OS and DFS.

Mentions: The prognostic impact of SIRT1 expression and Notch1 signaling was also analyzed in 122 of all 150 patients with breast carcinoma (because of the missing survival data in 28 patients). The relationship of SIRT1, N1IC, and Snail expression with OS and DFS was investigated using Kaplan–Meier survival curves (Figure 4). We found that low expression of SIRT1 significantly correlated with poor prognosis (p = 0.002 for both OS and DFS) (Figure 4A). Expression of N1IC and Snail did not display statistical difference with OS and DFS (Figure 4B,C).Figure 4


Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.

Cao YW, Li WQ, Wan GX, Li YX, Du XM, Li YC, Li F - J. Exp. Clin. Cancer Res. (2014)

Survival analyses for SIRT1, N1IC and Snail expression in breast cancer patients. A) Association of expression level of SIRT1 with OS and DFS. B) Association of expression level of N1IC with OS and DFS. C) Association of expression level of Snail with OS and DFS. D) Association of combined expression status of SIRT1 and N1IC with OS and DFS. E) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-low with OS and DFS. F) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-high with OS and DFS.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4248440&req=5

Fig4: Survival analyses for SIRT1, N1IC and Snail expression in breast cancer patients. A) Association of expression level of SIRT1 with OS and DFS. B) Association of expression level of N1IC with OS and DFS. C) Association of expression level of Snail with OS and DFS. D) Association of combined expression status of SIRT1 and N1IC with OS and DFS. E) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-low with OS and DFS. F) Association of SIRT1-low/N1IC-high and SIRT1-high/N1IC-high with OS and DFS.
Mentions: The prognostic impact of SIRT1 expression and Notch1 signaling was also analyzed in 122 of all 150 patients with breast carcinoma (because of the missing survival data in 28 patients). The relationship of SIRT1, N1IC, and Snail expression with OS and DFS was investigated using Kaplan–Meier survival curves (Figure 4). We found that low expression of SIRT1 significantly correlated with poor prognosis (p = 0.002 for both OS and DFS) (Figure 4A). Expression of N1IC and Snail did not display statistical difference with OS and DFS (Figure 4B,C).Figure 4

Bottom Line: The three markers significantly correlated with lymph node status.Patients with low SIRT1 expression exhibited shorter overall survival (OS) and disease-free survival (DFS), and patients with combined low expression of SIRT1 and high expression of N1IC had the worse OS and DFS.Univariate and multivariate survival analysis revealed that low expression of SIRT1 and SIRT1-low/N1IC-high expression were independent prognostic factors for poor survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, 832000, China. cywwb2013@126.com.

ABSTRACT

Background: SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined. The purpose of this study was to assess the possible prognostic value of SIRT1, N1IC, and Snail expression in breast cancer patients.

Methods: Immunohistochemistry was performed to examine the expression of SIRT1, N1IC, and Snail, and the combined expression of SIRT1 and N1IC, using tissue microarrays containing breast cancer tissue and matched adjacent normal breast tissue from 150 breast cancer patients. Survival analysis was carried out using the Kaplan-Meier method. Univariate and multivariate analysis were used to evaluate the prognostic value of SIRT1, N1IC, Snail and combined SIRT1/N1IC expression, in addition to other clinicopathological factors, including grade, lymph node status, disease stage, and estrogen, progesterone, and human epidermal growth factor receptor 2 receptor status in breast carcinoma patients.

Results: SIRT1, N1IC, and Snail were all found to be highly expressed and an inverse correlation between SIRT1 and N1IC in breast cancer tissue. The three markers significantly correlated with lymph node status. Patients with low SIRT1 expression exhibited shorter overall survival (OS) and disease-free survival (DFS), and patients with combined low expression of SIRT1 and high expression of N1IC had the worse OS and DFS. Univariate and multivariate survival analysis revealed that low expression of SIRT1 and SIRT1-low/N1IC-high expression were independent prognostic factors for poor survival.

Conclusions: These results suggest that low expression of SIRT1 or the combined low expression of SIRT1 and high expression of N1IC could be used as indicators of poor prognosis, and may represent novel therapeutic targets in breast cancer.

Show MeSH
Related in: MedlinePlus