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Skeletal myopathy in patients with chronic heart failure: significance of anabolic-androgenic hormones.

Josiak K, Jankowska EA, Piepoli MF, Banasiak W, Ponikowski P - J Cachexia Sarcopenia Muscle (2014)

Bottom Line: In heart failure, impairment of cardiac muscle function leads to numerous neurohormonal and metabolic disorders, including an imbalance between anabolic and catabolic processes, in favour of the latter.These disorders cause loss of muscle mass with structural and functional changes within the skeletal muscles, known as skeletal myopathy.This phenomenon constitutes an important mechanism that participates in the pathogenesis of chronic heart failure. both its clinical symptoms and the progression of the disease.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Heart Diseases, Wroclaw Medical University, Wroclaw, Poland, krystian85@hotmail.com.

ABSTRACT
In heart failure, impairment of cardiac muscle function leads to numerous neurohormonal and metabolic disorders, including an imbalance between anabolic and catabolic processes, in favour of the latter. These disorders cause loss of muscle mass with structural and functional changes within the skeletal muscles, known as skeletal myopathy. This phenomenon constitutes an important mechanism that participates in the pathogenesis of chronic heart failure. both its clinical symptoms and the progression of the disease. Attempts to reverse the above-mentioned pathologic processes by exploiting the anabolic action of androgenic hormones could provide a potentially attractive treatment option. The current concepts of anabolic androgen deficiency and resultant skeletal myopathy in patients with heart failure are reviewed, and the potential role of anabolic-androgenic hormones as an emerging therapeutic option for targeting heart failure is discussed.

No MeSH data available.


Related in: MedlinePlus

Mechanisms of action of anabolic hormones on skeletal muscles. AR androgen receptor, UPS ubiquitin-proteasome system)
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Fig2: Mechanisms of action of anabolic hormones on skeletal muscles. AR androgen receptor, UPS ubiquitin-proteasome system)

Mentions: Skeletal muscles contain steroid hormones (testosterone, DHEA/DHEAS, estradiol) and specific androgen and oestrogen receptors, as well as enzymes participating in mutual transformations of these hormones [48–52]. The mechanisms of androgenic hormones action on skeletal muscles are summarised in Fig. 2.Fig. 2


Skeletal myopathy in patients with chronic heart failure: significance of anabolic-androgenic hormones.

Josiak K, Jankowska EA, Piepoli MF, Banasiak W, Ponikowski P - J Cachexia Sarcopenia Muscle (2014)

Mechanisms of action of anabolic hormones on skeletal muscles. AR androgen receptor, UPS ubiquitin-proteasome system)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4248408&req=5

Fig2: Mechanisms of action of anabolic hormones on skeletal muscles. AR androgen receptor, UPS ubiquitin-proteasome system)
Mentions: Skeletal muscles contain steroid hormones (testosterone, DHEA/DHEAS, estradiol) and specific androgen and oestrogen receptors, as well as enzymes participating in mutual transformations of these hormones [48–52]. The mechanisms of androgenic hormones action on skeletal muscles are summarised in Fig. 2.Fig. 2

Bottom Line: In heart failure, impairment of cardiac muscle function leads to numerous neurohormonal and metabolic disorders, including an imbalance between anabolic and catabolic processes, in favour of the latter.These disorders cause loss of muscle mass with structural and functional changes within the skeletal muscles, known as skeletal myopathy.This phenomenon constitutes an important mechanism that participates in the pathogenesis of chronic heart failure. both its clinical symptoms and the progression of the disease.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Heart Diseases, Wroclaw Medical University, Wroclaw, Poland, krystian85@hotmail.com.

ABSTRACT
In heart failure, impairment of cardiac muscle function leads to numerous neurohormonal and metabolic disorders, including an imbalance between anabolic and catabolic processes, in favour of the latter. These disorders cause loss of muscle mass with structural and functional changes within the skeletal muscles, known as skeletal myopathy. This phenomenon constitutes an important mechanism that participates in the pathogenesis of chronic heart failure. both its clinical symptoms and the progression of the disease. Attempts to reverse the above-mentioned pathologic processes by exploiting the anabolic action of androgenic hormones could provide a potentially attractive treatment option. The current concepts of anabolic androgen deficiency and resultant skeletal myopathy in patients with heart failure are reviewed, and the potential role of anabolic-androgenic hormones as an emerging therapeutic option for targeting heart failure is discussed.

No MeSH data available.


Related in: MedlinePlus