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Evaluation of prothrombin time and activated partial thromboplastin time in hypertensive patients attending a tertiary hospital in calabar, Nigeria.

Nnenna Adaeze N, Uchenna Emeribe A, Abdullahi Nasiru I, Babayo A, Uko EK - Adv Hematol (2014)

Bottom Line: DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P < 0.05).DBP correlated negatively with duration of illness (r = -0.3097; P < 0.05) in hypertensive patients and positively with age of normotensive subjects (r = 0.3523; P < 0.05).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Science (Haematology and Blood Group Serology Unit), University of Calabar, PMB 1115, Calabar, Cross River State, Nigeria.

ABSTRACT
Introduction. Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension. Methods. This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar. Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods. Results. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r = 0.3072, r = 0.4988; P < 0.05) in hypertensive patients. DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P < 0.05). DBP correlated negatively with duration of illness (r = -0.3097; P < 0.05) in hypertensive patients and positively with age of normotensive subjects (r = 0.3523; P < 0.05). Conclusion. The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy. However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays.

No MeSH data available.


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Correlation plot of PTTK against PTT in normotensive subjects.
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fig6: Correlation plot of PTTK against PTT in normotensive subjects.

Mentions: Systolic blood pressure correlated positively with PTTK (r = 0.3072; P < 0.05) (Figure 4) and with diastolic blood pressure (r = 0.4988; P < 0.05) (Figure 2) in hypertensive patients, respectively. Diastolic blood pressure correlated negatively with duration of illness (r = −0.3097; P < 0.05) in hypertensive patients (Figure 1) and positively with age (r = 0.3523; P < 0.05) in normotensive subjects (Figure 5). A positive correlation was observed between PTT and PTTK both in hypertensive patients (r = 0.6217; P < 0.05) (Figure 3) and in normotensive subjects (r = 0.5886; P < 0.05) (Figure 6). More so positive correlation of systolic and diastolic blood pressure of normotensive subjects was observed across gender distribution (Figure 8) but negative correlation between systolic blood pressure and male hypertensive subjects (Figure 7). There was a statistical relationship between PT and APTT and age of hypertensive patients (P < 0.05) (Table 3). However there was no statistical relationship between PTT and APTT across ages of normotensive patients (Table 4).


Evaluation of prothrombin time and activated partial thromboplastin time in hypertensive patients attending a tertiary hospital in calabar, Nigeria.

Nnenna Adaeze N, Uchenna Emeribe A, Abdullahi Nasiru I, Babayo A, Uko EK - Adv Hematol (2014)

Correlation plot of PTTK against PTT in normotensive subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4248403&req=5

fig6: Correlation plot of PTTK against PTT in normotensive subjects.
Mentions: Systolic blood pressure correlated positively with PTTK (r = 0.3072; P < 0.05) (Figure 4) and with diastolic blood pressure (r = 0.4988; P < 0.05) (Figure 2) in hypertensive patients, respectively. Diastolic blood pressure correlated negatively with duration of illness (r = −0.3097; P < 0.05) in hypertensive patients (Figure 1) and positively with age (r = 0.3523; P < 0.05) in normotensive subjects (Figure 5). A positive correlation was observed between PTT and PTTK both in hypertensive patients (r = 0.6217; P < 0.05) (Figure 3) and in normotensive subjects (r = 0.5886; P < 0.05) (Figure 6). More so positive correlation of systolic and diastolic blood pressure of normotensive subjects was observed across gender distribution (Figure 8) but negative correlation between systolic blood pressure and male hypertensive subjects (Figure 7). There was a statistical relationship between PT and APTT and age of hypertensive patients (P < 0.05) (Table 3). However there was no statistical relationship between PTT and APTT across ages of normotensive patients (Table 4).

Bottom Line: DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P < 0.05).DBP correlated negatively with duration of illness (r = -0.3097; P < 0.05) in hypertensive patients and positively with age of normotensive subjects (r = 0.3523; P < 0.05).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Science (Haematology and Blood Group Serology Unit), University of Calabar, PMB 1115, Calabar, Cross River State, Nigeria.

ABSTRACT
Introduction. Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension. Methods. This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar. Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods. Results. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r = 0.3072, r = 0.4988; P < 0.05) in hypertensive patients. DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P < 0.05). DBP correlated negatively with duration of illness (r = -0.3097; P < 0.05) in hypertensive patients and positively with age of normotensive subjects (r = 0.3523; P < 0.05). Conclusion. The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy. However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays.

No MeSH data available.


Related in: MedlinePlus