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A large-scale cross-sectional study of ALK rearrangements and EGFR mutations in non-small-cell lung cancer in Chinese Han population.

Hong S, Fang W, Hu Z, Zhou T, Yan Y, Qin T, Tang Y, Ma Y, Zhao Y, Xue C, Huang Y, Zhao H, Zhang L - Sci Rep (2014)

Bottom Line: Multivariate logistic regression analysis was performed to explore the association between clinicopathological features and these two genetic aberrations.Receiver operating characteristic (ROC) curves methodology was applied to evaluate the predictive value.We showed that younger age at diagnosis was the only independent variable associated with EML4-ALK rearrangements (odds ratio (OR) per 5 years' increment, 0.68; p < 0.001), while lower tobacco exposure (OR per 5 pack-years' increment, 0.88; p < 0.001), adenocarcinoma (OR, 6.61; p < 0.001), and moderate to high differentiation (OR, 2.05; p < 0.001) were independently associated with EGFR mutations.

View Article: PubMed Central - PubMed

Affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.

ABSTRACT
The predictive power of age at diagnosis and smoking history for ALK rearrangements and EGFR mutations in non-small-cell lung cancer (NSCLC) remains not fully understood. In this cross-sectional study, 1160 NSCLC patients were prospectively enrolled and genotyped for EML4-ALK rearrangements and EGFR mutations. Multivariate logistic regression analysis was performed to explore the association between clinicopathological features and these two genetic aberrations. Receiver operating characteristic (ROC) curves methodology was applied to evaluate the predictive value. We showed that younger age at diagnosis was the only independent variable associated with EML4-ALK rearrangements (odds ratio (OR) per 5 years' increment, 0.68; p < 0.001), while lower tobacco exposure (OR per 5 pack-years' increment, 0.88; p < 0.001), adenocarcinoma (OR, 6.61; p < 0.001), and moderate to high differentiation (OR, 2.05; p < 0.001) were independently associated with EGFR mutations. Age at diagnosis was a very strong predictor of ALK rearrangements but poorly predicted EGFR mutations, while smoking pack-years may predict the presence of EGFR mutations and ALK rearrangements but with rather limited power. These findings should assist clinicians in assessing the likelihood of EML4-ALK rearrangements and EGFR mutations and understanding their biological implications in NSCLC.

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Related in: MedlinePlus

The incidence of EML4-ALK rearrangements, EGFR mutations, and WT/WT in non-small-cell lung cancer patients according to total smoking pack-years before diagnosis.WT/WT, wild type ALK and EGFR.
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f5: The incidence of EML4-ALK rearrangements, EGFR mutations, and WT/WT in non-small-cell lung cancer patients according to total smoking pack-years before diagnosis.WT/WT, wild type ALK and EGFR.

Mentions: The incidence of EML4-ALK rearrangements and EGFR mutations by smoking pack-years was shown in Figure 5. Briefly, the incidence of EGFR mutations decreased with increasing smoking pack-years. A 5 pack-years' increment led to a 12% decrease in the likelihood of EGFR mutations. However, there was a plateau of the incidence of EGFR mutations after more than 10 pack-years of cigarettes were consumed. Even in patients with more than 80 smoking pack-years, the incidence of EGFR mutations was as high as 13.2% (5/38). As for EML4-ALK rearrangements, the incidence peaked at 0–10 pack-years (20%) and then dropped with increasing cigarettes smoking.


A large-scale cross-sectional study of ALK rearrangements and EGFR mutations in non-small-cell lung cancer in Chinese Han population.

Hong S, Fang W, Hu Z, Zhou T, Yan Y, Qin T, Tang Y, Ma Y, Zhao Y, Xue C, Huang Y, Zhao H, Zhang L - Sci Rep (2014)

The incidence of EML4-ALK rearrangements, EGFR mutations, and WT/WT in non-small-cell lung cancer patients according to total smoking pack-years before diagnosis.WT/WT, wild type ALK and EGFR.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4248273&req=5

f5: The incidence of EML4-ALK rearrangements, EGFR mutations, and WT/WT in non-small-cell lung cancer patients according to total smoking pack-years before diagnosis.WT/WT, wild type ALK and EGFR.
Mentions: The incidence of EML4-ALK rearrangements and EGFR mutations by smoking pack-years was shown in Figure 5. Briefly, the incidence of EGFR mutations decreased with increasing smoking pack-years. A 5 pack-years' increment led to a 12% decrease in the likelihood of EGFR mutations. However, there was a plateau of the incidence of EGFR mutations after more than 10 pack-years of cigarettes were consumed. Even in patients with more than 80 smoking pack-years, the incidence of EGFR mutations was as high as 13.2% (5/38). As for EML4-ALK rearrangements, the incidence peaked at 0–10 pack-years (20%) and then dropped with increasing cigarettes smoking.

Bottom Line: Multivariate logistic regression analysis was performed to explore the association between clinicopathological features and these two genetic aberrations.Receiver operating characteristic (ROC) curves methodology was applied to evaluate the predictive value.We showed that younger age at diagnosis was the only independent variable associated with EML4-ALK rearrangements (odds ratio (OR) per 5 years' increment, 0.68; p < 0.001), while lower tobacco exposure (OR per 5 pack-years' increment, 0.88; p < 0.001), adenocarcinoma (OR, 6.61; p < 0.001), and moderate to high differentiation (OR, 2.05; p < 0.001) were independently associated with EGFR mutations.

View Article: PubMed Central - PubMed

Affiliation: 1] State Key Laboratory of Oncology in South China, Guangzhou, China [2] Collaborative Innovation Center for Cancer Medicine, Guangzhou, China [3] Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.

ABSTRACT
The predictive power of age at diagnosis and smoking history for ALK rearrangements and EGFR mutations in non-small-cell lung cancer (NSCLC) remains not fully understood. In this cross-sectional study, 1160 NSCLC patients were prospectively enrolled and genotyped for EML4-ALK rearrangements and EGFR mutations. Multivariate logistic regression analysis was performed to explore the association between clinicopathological features and these two genetic aberrations. Receiver operating characteristic (ROC) curves methodology was applied to evaluate the predictive value. We showed that younger age at diagnosis was the only independent variable associated with EML4-ALK rearrangements (odds ratio (OR) per 5 years' increment, 0.68; p < 0.001), while lower tobacco exposure (OR per 5 pack-years' increment, 0.88; p < 0.001), adenocarcinoma (OR, 6.61; p < 0.001), and moderate to high differentiation (OR, 2.05; p < 0.001) were independently associated with EGFR mutations. Age at diagnosis was a very strong predictor of ALK rearrangements but poorly predicted EGFR mutations, while smoking pack-years may predict the presence of EGFR mutations and ALK rearrangements but with rather limited power. These findings should assist clinicians in assessing the likelihood of EML4-ALK rearrangements and EGFR mutations and understanding their biological implications in NSCLC.

Show MeSH
Related in: MedlinePlus