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The efficacy of Jing Wan Hong ointment for nerve injury diabetic foot ulcer and its mechanisms.

Jin S, Zhang M, Gao Y, Zhang X, Cui G, Zhang Y - J Diabetes Res (2014)

Bottom Line: Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification.These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment.Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.

View Article: PubMed Central - PubMed

Affiliation: Tianjin Huanhu Hospital, Tianjin 300060, China.

ABSTRACT
Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.

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Related in: MedlinePlus

Results of the body weight and plasma glucose of the rats. (a) The body weight on day 0 and day 28 after administration (, n = 10). (b) The blood glucose on day 0 and day 28 after administration (, n = 10). There are no significant differences between all groups (P > 0.05).
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fig1: Results of the body weight and plasma glucose of the rats. (a) The body weight on day 0 and day 28 after administration (, n = 10). (b) The blood glucose on day 0 and day 28 after administration (, n = 10). There are no significant differences between all groups (P > 0.05).

Mentions: After STZ injection, the rats developed typical symptoms of diabetes, and their plasma glucose became more than 16.65 mmol/L. However, there were no significant differences in the body weight and blood glucose levels between all groups on day 0 (F = 0.115 or 0.059, P > 0.05) and day 28 (F = 0.224 or 1.286, P > 0.05) after administration as shown in Figure 1.


The efficacy of Jing Wan Hong ointment for nerve injury diabetic foot ulcer and its mechanisms.

Jin S, Zhang M, Gao Y, Zhang X, Cui G, Zhang Y - J Diabetes Res (2014)

Results of the body weight and plasma glucose of the rats. (a) The body weight on day 0 and day 28 after administration (, n = 10). (b) The blood glucose on day 0 and day 28 after administration (, n = 10). There are no significant differences between all groups (P > 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4247915&req=5

fig1: Results of the body weight and plasma glucose of the rats. (a) The body weight on day 0 and day 28 after administration (, n = 10). (b) The blood glucose on day 0 and day 28 after administration (, n = 10). There are no significant differences between all groups (P > 0.05).
Mentions: After STZ injection, the rats developed typical symptoms of diabetes, and their plasma glucose became more than 16.65 mmol/L. However, there were no significant differences in the body weight and blood glucose levels between all groups on day 0 (F = 0.115 or 0.059, P > 0.05) and day 28 (F = 0.224 or 1.286, P > 0.05) after administration as shown in Figure 1.

Bottom Line: Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification.These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment.Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.

View Article: PubMed Central - PubMed

Affiliation: Tianjin Huanhu Hospital, Tianjin 300060, China.

ABSTRACT
Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.

Show MeSH
Related in: MedlinePlus