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Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.

Cai Y, Wang J, Zhang L, Wu D, Yu D, Tian X, Liu J, Jiang X, Shen Y, Zhang L, Ren M, Huang P - Med. Oncol. (2014)

Bottom Line: Tissue array was conducted by using a tissue microarray instrument.HER2 was also stained to be distributed in the cell cytoplasm associated with higher expression in high-grade cancer.These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Obestetrics and Gynecology, Zhongda Hospital, Southeast University, Dingjia Qiao Road 87, Nanjing, 210009, Jiangsu Province, China.

ABSTRACT
The present study was designed to explore the cross talk between fatty acid synthase (FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 ovarian cancer patients and 15 normal ovarian tissues were enrolled. Tissue array was conducted by using a tissue microarray instrument. Immunohistochemistry was performed to quantify the expressions of HER2 and FASN. The FASN was detected to be distributed in the cell cytoplasm and was significantly correlated with cancer grade (p = 0.000) and FIGO staging (p = 0.000). Patients with FASN overexpression in ovarian cancer tend to have a worse overall survival rate (p = 0.000). HER2 was also stained to be distributed in the cell cytoplasm associated with higher expression in high-grade cancer. It was also disclosed that FASN expression level is not correlated with HER2 status in ovarian cancer. These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer.

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Related in: MedlinePlus

Overall survival based on the expression of FASN. Kaplan–Meier survival analysis showing that high expression of FASN (++ and +++) was associated with a shorter overall survival in comparison with low FASN expression (0 and +) in ovarian cancer (p = 0.000, log-rank test)
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Fig2: Overall survival based on the expression of FASN. Kaplan–Meier survival analysis showing that high expression of FASN (++ and +++) was associated with a shorter overall survival in comparison with low FASN expression (0 and +) in ovarian cancer (p = 0.000, log-rank test)

Mentions: FASN was detected to be distributed in the cell cytoplasm and high FASN expression levels were observed in 70.5 % (67/95) of analyzed tumors. There was no FASN immunoreactivity (0/15) in the normal ovarian tissues (Fig. 1). Depending on FASN immunostaining score, patients were divided into high expression (2+ and 3+) and low expression (− and +) groups. There was no significant association between FASN status and histological type (p = 0.06), patients age (p = 0.650), residual tumor (p = 0.455). However, cancer grade (p = 0.000) and FIGO staging (p = 0.000) were significantly correlated with FASN expression (Table 1). Patients with FASN overexpression in ovarian cancer tend to have a worse overall survival rate (p = 0.000) (Fig. 2).Fig. 1


Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.

Cai Y, Wang J, Zhang L, Wu D, Yu D, Tian X, Liu J, Jiang X, Shen Y, Zhang L, Ren M, Huang P - Med. Oncol. (2014)

Overall survival based on the expression of FASN. Kaplan–Meier survival analysis showing that high expression of FASN (++ and +++) was associated with a shorter overall survival in comparison with low FASN expression (0 and +) in ovarian cancer (p = 0.000, log-rank test)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4247847&req=5

Fig2: Overall survival based on the expression of FASN. Kaplan–Meier survival analysis showing that high expression of FASN (++ and +++) was associated with a shorter overall survival in comparison with low FASN expression (0 and +) in ovarian cancer (p = 0.000, log-rank test)
Mentions: FASN was detected to be distributed in the cell cytoplasm and high FASN expression levels were observed in 70.5 % (67/95) of analyzed tumors. There was no FASN immunoreactivity (0/15) in the normal ovarian tissues (Fig. 1). Depending on FASN immunostaining score, patients were divided into high expression (2+ and 3+) and low expression (− and +) groups. There was no significant association between FASN status and histological type (p = 0.06), patients age (p = 0.650), residual tumor (p = 0.455). However, cancer grade (p = 0.000) and FIGO staging (p = 0.000) were significantly correlated with FASN expression (Table 1). Patients with FASN overexpression in ovarian cancer tend to have a worse overall survival rate (p = 0.000) (Fig. 2).Fig. 1

Bottom Line: Tissue array was conducted by using a tissue microarray instrument.HER2 was also stained to be distributed in the cell cytoplasm associated with higher expression in high-grade cancer.These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Obestetrics and Gynecology, Zhongda Hospital, Southeast University, Dingjia Qiao Road 87, Nanjing, 210009, Jiangsu Province, China.

ABSTRACT
The present study was designed to explore the cross talk between fatty acid synthase (FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 ovarian cancer patients and 15 normal ovarian tissues were enrolled. Tissue array was conducted by using a tissue microarray instrument. Immunohistochemistry was performed to quantify the expressions of HER2 and FASN. The FASN was detected to be distributed in the cell cytoplasm and was significantly correlated with cancer grade (p = 0.000) and FIGO staging (p = 0.000). Patients with FASN overexpression in ovarian cancer tend to have a worse overall survival rate (p = 0.000). HER2 was also stained to be distributed in the cell cytoplasm associated with higher expression in high-grade cancer. It was also disclosed that FASN expression level is not correlated with HER2 status in ovarian cancer. These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer.

Show MeSH
Related in: MedlinePlus