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Distribution of anticoagulant rodenticide resistance in Rattus norvegicus in the Netherlands according to Vkorc1 mutations.

Meerburg BG, van Gent-Pelzer MP, Schoelitsz B, Esther A, van der Lee TA - Pest Manag. Sci. (2014)

Bottom Line: Here, the authors present the results of a survey in the Netherlands where tissue samples and droppings were tested using a newly developed TaqMan PCR test for genotypic variation at codon 139 in the Vkorc1 gene associated with anticoagulant rodenticide resistance.In addition, indications of a clear genetic substructure in the Netherlands were found.As rodenticides should keep their efficacy because they are a last resort in rodent management, more studies are urgently needed that link specific genetic mutations to the efficacy of active substances.

View Article: PubMed Central - PubMed

Affiliation: Wageningen UR Livestock Research, Lelystad, The Netherlands.

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Related in: MedlinePlus

Spatial distribution of mutations at codon 139 of the Vkorc1 gene in R. norvegicus in the Netherlands, based on dropping samples. The grey areas are regions with reliable genotyping results. A: the light-grey areas are regions with heterozygous Tyr-Cys genotypes, and the dark-grey areas are regions with heterozygous Tyr-Phe genotypes. B: the light-grey areas are regions where homozygous Tyr-Cys genotypes were encountered, and the dark-grey areas are regions where homozygous Tyr-Phe genotypes were found. Numbers in parentheses show the number of positive specimens in that area.
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fig02: Spatial distribution of mutations at codon 139 of the Vkorc1 gene in R. norvegicus in the Netherlands, based on dropping samples. The grey areas are regions with reliable genotyping results. A: the light-grey areas are regions with heterozygous Tyr-Cys genotypes, and the dark-grey areas are regions with heterozygous Tyr-Phe genotypes. B: the light-grey areas are regions where homozygous Tyr-Cys genotypes were encountered, and the dark-grey areas are regions where homozygous Tyr-Phe genotypes were found. Numbers in parentheses show the number of positive specimens in that area.

Mentions: The distribution of resistance-mediating genotypes and the distribution of heterozygous and homozygous mutants seem to be uneven in the Netherlands (Fig. 2).


Distribution of anticoagulant rodenticide resistance in Rattus norvegicus in the Netherlands according to Vkorc1 mutations.

Meerburg BG, van Gent-Pelzer MP, Schoelitsz B, Esther A, van der Lee TA - Pest Manag. Sci. (2014)

Spatial distribution of mutations at codon 139 of the Vkorc1 gene in R. norvegicus in the Netherlands, based on dropping samples. The grey areas are regions with reliable genotyping results. A: the light-grey areas are regions with heterozygous Tyr-Cys genotypes, and the dark-grey areas are regions with heterozygous Tyr-Phe genotypes. B: the light-grey areas are regions where homozygous Tyr-Cys genotypes were encountered, and the dark-grey areas are regions where homozygous Tyr-Phe genotypes were found. Numbers in parentheses show the number of positive specimens in that area.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4238836&req=5

fig02: Spatial distribution of mutations at codon 139 of the Vkorc1 gene in R. norvegicus in the Netherlands, based on dropping samples. The grey areas are regions with reliable genotyping results. A: the light-grey areas are regions with heterozygous Tyr-Cys genotypes, and the dark-grey areas are regions with heterozygous Tyr-Phe genotypes. B: the light-grey areas are regions where homozygous Tyr-Cys genotypes were encountered, and the dark-grey areas are regions where homozygous Tyr-Phe genotypes were found. Numbers in parentheses show the number of positive specimens in that area.
Mentions: The distribution of resistance-mediating genotypes and the distribution of heterozygous and homozygous mutants seem to be uneven in the Netherlands (Fig. 2).

Bottom Line: Here, the authors present the results of a survey in the Netherlands where tissue samples and droppings were tested using a newly developed TaqMan PCR test for genotypic variation at codon 139 in the Vkorc1 gene associated with anticoagulant rodenticide resistance.In addition, indications of a clear genetic substructure in the Netherlands were found.As rodenticides should keep their efficacy because they are a last resort in rodent management, more studies are urgently needed that link specific genetic mutations to the efficacy of active substances.

View Article: PubMed Central - PubMed

Affiliation: Wageningen UR Livestock Research, Lelystad, The Netherlands.

Show MeSH
Related in: MedlinePlus