High-sensitivity CRP is an independent risk factor for all fractures and vertebral fractures in elderly men: the MrOS Sweden study.
Bottom Line: Study participants were divided into tertile groups based on hs-CRP level.Femoral neck bone mineral density (BMD) was not associated with hs-CRP, and the predictive role of hs-CRP for fracture risk was essentially unchanged when femoral neck BMD was added to the model (HR, 1.37; 95% CI, 1.09-1.72).This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Affiliation: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.Show MeSH
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Mentions: Cox proportional hazards models demonstrated that high serum hs-CRP was related to an increased risk of first fracture (age-adjusted HR, 1.25; 95% CI, 1.10–1.42 per tertile increase in hs-CRP). The fracture risk for subjects in the highest CRP tertile was clearly increased compared with subjects in the lowest tertile (HR, 1.54; 95% CI, 1.20–1.97), whereas the fracture risk was similar in the medium CRP tertile compared with the lowest CRP tertile (HR, 1.10; 95% CI, 0.85–1.43). Therefore, the lowest and the medium tertiles were pooled into one group in the subsequent analyses. The HR of fracture for the highest tertile of hs-CRP, compared with the lowest and the medium tertiles combined, was 1.48 (95% CI, 1.20–1.82; Fig. 1A).
Affiliation: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.