Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics.
Bottom Line: A wide range of domesticated animals, including sheep, goats, cattle, pigs, dogs, and chickens have been proven seropositive for SFTSV.Ticks, especially Haemaphysalis longicornis, are suspected to be the potential vector, which have a broad animal host range in the world.More studies are needed to elucidate the vector-animal-human ecological cycle, the pathogenic mechanisms in high level animal models and vaccine development.
Affiliation: Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China.Show MeSH
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Mentions: Severe fever with thrombocytopenia syndrome virus, such as other Bunyaviridae, is a spherical virion of 80–100 nm in diameter, covered by a lipid bilayer envelope of 5–7 nm in thickness, with no Ms 1,2,11,15. The lipid bilayer envelope has spikes composed of gps, regularly arranged in genus specific arrays on the envelope exterior 1,2,16,17. As observed by thin-section EM, the interior of the virions has a filamentous or coiled bead appearance, composed of three viral segments wrapped in the viral N in a circular genome 1,2,17,18 (Figure 1).
Affiliation: Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China.