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Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics.

Liu S, Chai C, Wang C, Amer S, Lv H, He H, Sun J, Lin J - Rev. Med. Virol. (2013)

Bottom Line: A wide range of domesticated animals, including sheep, goats, cattle, pigs, dogs, and chickens have been proven seropositive for SFTSV.Ticks, especially Haemaphysalis longicornis, are suspected to be the potential vector, which have a broad animal host range in the world.More studies are needed to elucidate the vector-animal-human ecological cycle, the pathogenic mechanisms in high level animal models and vaccine development.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China.

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Related in: MedlinePlus

Schematic diagram of the structure and genome of the SFTSV 1,2. SFTSV genome included L, M, and S segments. The antisense RNA and the encoded ORFs are represented in orange and blue boxes respectively. In L, M, and S genomic RNAs, only the first 20 Nts of both the 5′ and 3′ termini of each segment are shown. The first 15 Nts of both the 5′ and 3′ termini of each segment are paired and conserved except for the mismatches A–C/G or C–U in red color and C–C or G–G in blue color. Note: The data were sourced from the report of Li et al. and processed in photoshop 7.0 1
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fig01: Schematic diagram of the structure and genome of the SFTSV 1,2. SFTSV genome included L, M, and S segments. The antisense RNA and the encoded ORFs are represented in orange and blue boxes respectively. In L, M, and S genomic RNAs, only the first 20 Nts of both the 5′ and 3′ termini of each segment are shown. The first 15 Nts of both the 5′ and 3′ termini of each segment are paired and conserved except for the mismatches A–C/G or C–U in red color and C–C or G–G in blue color. Note: The data were sourced from the report of Li et al. and processed in photoshop 7.0 1

Mentions: Severe fever with thrombocytopenia syndrome virus, such as other Bunyaviridae, is a spherical virion of 80–100 nm in diameter, covered by a lipid bilayer envelope of 5–7 nm in thickness, with no Ms 1,2,11,15. The lipid bilayer envelope has spikes composed of gps, regularly arranged in genus specific arrays on the envelope exterior 1,2,16,17. As observed by thin-section EM, the interior of the virions has a filamentous or coiled bead appearance, composed of three viral segments wrapped in the viral N in a circular genome 1,2,17,18 (Figure 1).


Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics.

Liu S, Chai C, Wang C, Amer S, Lv H, He H, Sun J, Lin J - Rev. Med. Virol. (2013)

Schematic diagram of the structure and genome of the SFTSV 1,2. SFTSV genome included L, M, and S segments. The antisense RNA and the encoded ORFs are represented in orange and blue boxes respectively. In L, M, and S genomic RNAs, only the first 20 Nts of both the 5′ and 3′ termini of each segment are shown. The first 15 Nts of both the 5′ and 3′ termini of each segment are paired and conserved except for the mismatches A–C/G or C–U in red color and C–C or G–G in blue color. Note: The data were sourced from the report of Li et al. and processed in photoshop 7.0 1
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4237196&req=5

fig01: Schematic diagram of the structure and genome of the SFTSV 1,2. SFTSV genome included L, M, and S segments. The antisense RNA and the encoded ORFs are represented in orange and blue boxes respectively. In L, M, and S genomic RNAs, only the first 20 Nts of both the 5′ and 3′ termini of each segment are shown. The first 15 Nts of both the 5′ and 3′ termini of each segment are paired and conserved except for the mismatches A–C/G or C–U in red color and C–C or G–G in blue color. Note: The data were sourced from the report of Li et al. and processed in photoshop 7.0 1
Mentions: Severe fever with thrombocytopenia syndrome virus, such as other Bunyaviridae, is a spherical virion of 80–100 nm in diameter, covered by a lipid bilayer envelope of 5–7 nm in thickness, with no Ms 1,2,11,15. The lipid bilayer envelope has spikes composed of gps, regularly arranged in genus specific arrays on the envelope exterior 1,2,16,17. As observed by thin-section EM, the interior of the virions has a filamentous or coiled bead appearance, composed of three viral segments wrapped in the viral N in a circular genome 1,2,17,18 (Figure 1).

Bottom Line: A wide range of domesticated animals, including sheep, goats, cattle, pigs, dogs, and chickens have been proven seropositive for SFTSV.Ticks, especially Haemaphysalis longicornis, are suspected to be the potential vector, which have a broad animal host range in the world.More studies are needed to elucidate the vector-animal-human ecological cycle, the pathogenic mechanisms in high level animal models and vaccine development.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, Zhejiang Province, China.

Show MeSH
Related in: MedlinePlus