Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system.
Bottom Line: Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase.At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses.We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord.
Affiliation: Medical University Vienna, Center for Brain Research, Department of Neuroimmunology, Spitalgasse 4, 1090, Vienna, Austria.Show MeSH
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Mentions: It has been described that TSLP preferentially stimulates myeloid cells (Qiao et al., 2011; Reche et al., 2001), and that DCs and monocytes coexpress TSLPR and IL-7Rα (Reche et al., 2001). Since microglia and monocytes share the ability to differentiate along the macrophage and DC lineage under several different pathological conditions (Fischer and Reichmann, 2001; Reichmann et al., 2002; Santambrogio et al., 2001), we analyzed by qPCR whether DCs from the meningeal DC network or microglial cells from the spinal cord contain the molecular machinery needed for TSLP recognition, that is, a functional TSLP receptor dimer consisting of the TSLP-specific receptor chain (TSLPR) and the common IL-7 receptor alpha chain (IL-7Rα). We found that the meningeal MHC class II+ DCs and spinal cord microglia produced transcripts encoding both the IL-7Rα chain and the TSLPR and were hence able to form a functional receptor for TSLP recognition (Fig. 3).
Affiliation: Medical University Vienna, Center for Brain Research, Department of Neuroimmunology, Spitalgasse 4, 1090, Vienna, Austria.