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Effects of millimeter wave irradiation and equivalent thermal heating on the activity of individual neurons in the leech ganglion.

Romanenko S, Siegel PH, Wagenaar DA, Pikov V - J. Neurophysiol. (2014)

Bottom Line: Many of today's radiofrequency-emitting devices in telecommunication, telemedicine, transportation safety, and security/military applications use the millimeter wave (MMW) band (30-300 GHz).For comparison, the recognized U.S. safe exposure limit is 1 mW/cm(2) for 6 min.During the exposure to MMWs and gradual bath heating at a rate of 0.04°C/s (2.4°C/min), the ganglionic neurons exhibited similar dose-dependent hyperpolarization of the plasma membrane and decrease in the action potential amplitude.

View Article: PubMed Central - PubMed

Affiliation: Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California; Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, California; and.

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Representative recordings of the electrophysiological activity in the Retzius cell (A and B), calculated firing rate (C and D), and bath temperature (E and F) during 60-s application of MMW irradiation (60 GHz, 4 mW/cm2; A, C, E) and gradual bath heating (at a rate of 0.04°C/s; B, D, F). Calculation of the firing rate was based on the interspike intervals averaged for every 10 s. The shaded red area indicates the interval of MMW irradiation, and the shaded gray area indicates the interval of gradual bath heating.
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Figure 2: Representative recordings of the electrophysiological activity in the Retzius cell (A and B), calculated firing rate (C and D), and bath temperature (E and F) during 60-s application of MMW irradiation (60 GHz, 4 mW/cm2; A, C, E) and gradual bath heating (at a rate of 0.04°C/s; B, D, F). Calculation of the firing rate was based on the interspike intervals averaged for every 10 s. The shaded red area indicates the interval of MMW irradiation, and the shaded gray area indicates the interval of gradual bath heating.

Mentions: The MMW effects at multiple incident power densities were analyzed using the SPSS general linear model (SPSS, Chicago, IL), followed by Dunnet one-sided post hoc t-tests for the postirradiation data compared with preirradiation controls. The bath heating effects were analyzed using the linear regression model (SPSS), and closeness of the fit is expressed as the adjusted coefficient of determination (R2). Comparison of the MMW and bath heating effects in Fig. 5 was performed using the one-tailed t-test. The significance levels of 0.05, 0.01, and 0.001 were used. The results are reported as means ± SE (except for Fig. 2, where values are means ± SD).


Effects of millimeter wave irradiation and equivalent thermal heating on the activity of individual neurons in the leech ganglion.

Romanenko S, Siegel PH, Wagenaar DA, Pikov V - J. Neurophysiol. (2014)

Representative recordings of the electrophysiological activity in the Retzius cell (A and B), calculated firing rate (C and D), and bath temperature (E and F) during 60-s application of MMW irradiation (60 GHz, 4 mW/cm2; A, C, E) and gradual bath heating (at a rate of 0.04°C/s; B, D, F). Calculation of the firing rate was based on the interspike intervals averaged for every 10 s. The shaded red area indicates the interval of MMW irradiation, and the shaded gray area indicates the interval of gradual bath heating.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4233276&req=5

Figure 2: Representative recordings of the electrophysiological activity in the Retzius cell (A and B), calculated firing rate (C and D), and bath temperature (E and F) during 60-s application of MMW irradiation (60 GHz, 4 mW/cm2; A, C, E) and gradual bath heating (at a rate of 0.04°C/s; B, D, F). Calculation of the firing rate was based on the interspike intervals averaged for every 10 s. The shaded red area indicates the interval of MMW irradiation, and the shaded gray area indicates the interval of gradual bath heating.
Mentions: The MMW effects at multiple incident power densities were analyzed using the SPSS general linear model (SPSS, Chicago, IL), followed by Dunnet one-sided post hoc t-tests for the postirradiation data compared with preirradiation controls. The bath heating effects were analyzed using the linear regression model (SPSS), and closeness of the fit is expressed as the adjusted coefficient of determination (R2). Comparison of the MMW and bath heating effects in Fig. 5 was performed using the one-tailed t-test. The significance levels of 0.05, 0.01, and 0.001 were used. The results are reported as means ± SE (except for Fig. 2, where values are means ± SD).

Bottom Line: Many of today's radiofrequency-emitting devices in telecommunication, telemedicine, transportation safety, and security/military applications use the millimeter wave (MMW) band (30-300 GHz).For comparison, the recognized U.S. safe exposure limit is 1 mW/cm(2) for 6 min.During the exposure to MMWs and gradual bath heating at a rate of 0.04°C/s (2.4°C/min), the ganglionic neurons exhibited similar dose-dependent hyperpolarization of the plasma membrane and decrease in the action potential amplitude.

View Article: PubMed Central - PubMed

Affiliation: Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California; Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, California; and.

Show MeSH
Related in: MedlinePlus