Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse.
Bottom Line: However, global gene expression profiles determined for 17 of these patients revealed a mixed-polarization phenotype unrelated to the M1/M2 classification.CD163 surface expression also correlated with the ascites levels of IL-6 and IL-10 (p < 0.05), both cytokines induced CD163 expression, and their ascites levels showed a clear inverse association with RFS (p < 0.01).These findings define a subgroup of patients with high CD163 expression, high IL-6 and/or IL-10 levels and poor clinical outcome.
Affiliation: Clinic for Gynecology, Gynecological Oncology and Gynecological Endocrinology, Philipps University, Marburg, Germany.Show MeSH
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Mentions: The data described above raised the possibility that the expression of CD163 on TAMs and the ascites levels of cytokines might be linked. Therefore, we tested this hypothesis for pairs of the respective datasets (i.e., CD163 and cytokine values for the same patient) using Pearson’s r (Supporting Information Table S2). This analysis indeed confirmed a significant correlation of CD163 expression with the concentration of both IL-6 (p = 0.0483; correlation coefficient r = 0.1471; Fig. 4a) and IL-10 (p = 0.0459; r = 0.1501; Fig. 4b). None of the other cytokines tested was significantly associated with CD163 expression (Supporting Information Table S2).
Affiliation: Clinic for Gynecology, Gynecological Oncology and Gynecological Endocrinology, Philipps University, Marburg, Germany.