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Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy.

Rodríguez-Carrizalez AD, Castellanos-González JA, Martínez-Romero EC, Miller-Arrevillaga G, Villa-Hernández D, Hernández-Godínez PP, Ortiz GG, Pacheco-Moisés FP, Cardona-Muñoz EG, Miranda-Díaz AG - J Diabetes (2013)

Bottom Line: TAC had significant decrease levels with minimum peak in severe retinopathy with 7.98 ± 0.48 mEq/mL (P < 0.0001).The fluidity of membrane submitochondrial particles decreased significantly in T2DM patients with mild, moderate, or severe NPDR compared with that in healthy volunteers (P < 0.0001 for all).Patients with NPDR exhibit oxidative deregulation with decreased membrane fluidity of submitochondrial particles and increased systemic catabolism (mitochondrial dysfunction) with the potential for generalized systemic damage in T2DM.

View Article: PubMed Central - PubMed

Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.

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Results of Spearman's correlation tests. Significant positive correlations were found between (a) the products of lipid peroxidation (LPO) and nitric oxide (NO), as well as between (b) LPO and diminished total antioxidant capacity (TAC; P < 0.010). In addition, significant positive correlations were found between (c) LPO and uric acid (P < 0.025), (d) increased catalase and glutathione peroxidase (GPx) activity (P < 0.007), and (e) increased NOx levels and TAC (P < 0.010). We can assume that there is oxidant, antioxidant, and mitochondrial dysregulation in chronic type 2 diabetes mellitus.
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fig03: Results of Spearman's correlation tests. Significant positive correlations were found between (a) the products of lipid peroxidation (LPO) and nitric oxide (NO), as well as between (b) LPO and diminished total antioxidant capacity (TAC; P < 0.010). In addition, significant positive correlations were found between (c) LPO and uric acid (P < 0.025), (d) increased catalase and glutathione peroxidase (GPx) activity (P < 0.007), and (e) increased NOx levels and TAC (P < 0.010). We can assume that there is oxidant, antioxidant, and mitochondrial dysregulation in chronic type 2 diabetes mellitus.

Mentions: We found a positive correlation between elevated levels of LPO and NO, demonstrating the presence of oxidative and/or nitrosative stress that could contribute to the pathogenesis and progression of DR (Fig. 3a). In addition, there was a positive correlation between uric acid and LPO levels, which may reflect a compensatory mechanism for the oxidative state caused by the persistent hyperglycemia (Fig. 3c). Furthermore, there were positive correlations between LPO and NOx with a decrease in TAC (Fig. 3b,e). There was an increased consumption of TAC defenses with progressive increases in LPO and NO due to lack of metabolic control. There was also a positive correlation between increased GPx and catalase activity. This could be related to a compensatory mechanism to prevent tissue damage via an increase in these two antioxidant enzyme systems (Fig. 3d).


Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy.

Rodríguez-Carrizalez AD, Castellanos-González JA, Martínez-Romero EC, Miller-Arrevillaga G, Villa-Hernández D, Hernández-Godínez PP, Ortiz GG, Pacheco-Moisés FP, Cardona-Muñoz EG, Miranda-Díaz AG - J Diabetes (2013)

Results of Spearman's correlation tests. Significant positive correlations were found between (a) the products of lipid peroxidation (LPO) and nitric oxide (NO), as well as between (b) LPO and diminished total antioxidant capacity (TAC; P < 0.010). In addition, significant positive correlations were found between (c) LPO and uric acid (P < 0.025), (d) increased catalase and glutathione peroxidase (GPx) activity (P < 0.007), and (e) increased NOx levels and TAC (P < 0.010). We can assume that there is oxidant, antioxidant, and mitochondrial dysregulation in chronic type 2 diabetes mellitus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232896&req=5

fig03: Results of Spearman's correlation tests. Significant positive correlations were found between (a) the products of lipid peroxidation (LPO) and nitric oxide (NO), as well as between (b) LPO and diminished total antioxidant capacity (TAC; P < 0.010). In addition, significant positive correlations were found between (c) LPO and uric acid (P < 0.025), (d) increased catalase and glutathione peroxidase (GPx) activity (P < 0.007), and (e) increased NOx levels and TAC (P < 0.010). We can assume that there is oxidant, antioxidant, and mitochondrial dysregulation in chronic type 2 diabetes mellitus.
Mentions: We found a positive correlation between elevated levels of LPO and NO, demonstrating the presence of oxidative and/or nitrosative stress that could contribute to the pathogenesis and progression of DR (Fig. 3a). In addition, there was a positive correlation between uric acid and LPO levels, which may reflect a compensatory mechanism for the oxidative state caused by the persistent hyperglycemia (Fig. 3c). Furthermore, there were positive correlations between LPO and NOx with a decrease in TAC (Fig. 3b,e). There was an increased consumption of TAC defenses with progressive increases in LPO and NO due to lack of metabolic control. There was also a positive correlation between increased GPx and catalase activity. This could be related to a compensatory mechanism to prevent tissue damage via an increase in these two antioxidant enzyme systems (Fig. 3d).

Bottom Line: TAC had significant decrease levels with minimum peak in severe retinopathy with 7.98 ± 0.48 mEq/mL (P < 0.0001).The fluidity of membrane submitochondrial particles decreased significantly in T2DM patients with mild, moderate, or severe NPDR compared with that in healthy volunteers (P < 0.0001 for all).Patients with NPDR exhibit oxidative deregulation with decreased membrane fluidity of submitochondrial particles and increased systemic catabolism (mitochondrial dysfunction) with the potential for generalized systemic damage in T2DM.

View Article: PubMed Central - PubMed

Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.

Show MeSH
Related in: MedlinePlus