Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy.
Bottom Line: TAC had significant decrease levels with minimum peak in severe retinopathy with 7.98 ± 0.48 mEq/mL (P < 0.0001).The fluidity of membrane submitochondrial particles decreased significantly in T2DM patients with mild, moderate, or severe NPDR compared with that in healthy volunteers (P < 0.0001 for all).Patients with NPDR exhibit oxidative deregulation with decreased membrane fluidity of submitochondrial particles and increased systemic catabolism (mitochondrial dysfunction) with the potential for generalized systemic damage in T2DM.
Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.Show MeSH
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Mentions: We found a positive correlation between elevated levels of LPO and NO, demonstrating the presence of oxidative and/or nitrosative stress that could contribute to the pathogenesis and progression of DR (Fig. 3a). In addition, there was a positive correlation between uric acid and LPO levels, which may reflect a compensatory mechanism for the oxidative state caused by the persistent hyperglycemia (Fig. 3c). Furthermore, there were positive correlations between LPO and NOx with a decrease in TAC (Fig. 3b,e). There was an increased consumption of TAC defenses with progressive increases in LPO and NO due to lack of metabolic control. There was also a positive correlation between increased GPx and catalase activity. This could be related to a compensatory mechanism to prevent tissue damage via an increase in these two antioxidant enzyme systems (Fig. 3d).
Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.