Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy.
Bottom Line: TAC had significant decrease levels with minimum peak in severe retinopathy with 7.98 ± 0.48 mEq/mL (P < 0.0001).The fluidity of membrane submitochondrial particles decreased significantly in T2DM patients with mild, moderate, or severe NPDR compared with that in healthy volunteers (P < 0.0001 for all).Patients with NPDR exhibit oxidative deregulation with decreased membrane fluidity of submitochondrial particles and increased systemic catabolism (mitochondrial dysfunction) with the potential for generalized systemic damage in T2DM.
Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.Show MeSH
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Mentions: The Ie/Im ratio in the healthy control group was 0.24 ± 0.01. The Ie/Im ratio decreased significantly in T2DM patients with mild, moderate, and severe NPDR (0.12 ± 0.01, 0.16 ± 0.02, and 0.13 ± 0.01, respectively; P < 0.0001). The decrease in fluidity compared with the control group could be related to the effect that the fluidity of the membrane has on membrane potential induced by the increase in HbA1c, dyslipidemia, oxidative stress or their combination (Fig. 2a).
Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.