Oxidants, antioxidants and mitochondrial function in non-proliferative diabetic retinopathy.
Bottom Line: TAC had significant decrease levels with minimum peak in severe retinopathy with 7.98 ± 0.48 mEq/mL (P < 0.0001).The fluidity of membrane submitochondrial particles decreased significantly in T2DM patients with mild, moderate, or severe NPDR compared with that in healthy volunteers (P < 0.0001 for all).Patients with NPDR exhibit oxidative deregulation with decreased membrane fluidity of submitochondrial particles and increased systemic catabolism (mitochondrial dysfunction) with the potential for generalized systemic damage in T2DM.
Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.Show MeSH
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Mentions: Levels of LPO products in healthy controls were 0.98 ± 0.13 μmol/L. These increased significantly with the severity of retinopathy from 1.42 ± 0.08 to 2.49 ± 0.05, and 3.29 ± 0.05 μmol/L (mild, moderate, and severe NPDR, respectively; P < 0.017; Fig. 1a), suggesting the presence of oxidative stress in NPDR. Because LPO is a well-established mechanism of cellular lesions, these findings suggest cellular and systemic oxidative stress.
Affiliation: University Health Sciences Centre, University of Guadalajara, Guadalajara, México.