Paroxysmal nocturnal hemoglobinuria: a single Spanish center's experience over the last 40 yr.
Bottom Line: The average clonal size upon diagnosis was 48%, presenting a variable evolution.Thrombotic episodes and cancer were five each, and the main causes of death among our patients were equal at 8.9%.Sixteen patients have been treated with eculizumab so far in our series, and being a safe drug, it provides improvement in the patients' quality of life, and the disappearance of clinical symptoms, and avoids the emergence of new thrombosis.
Affiliation: Hematology Service, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.Show MeSH
Related in: MedlinePlus
Mentions: The most severe clinical expressivity attributable to hemolysis, including thrombotic events, is represented in the group of patients with classic disease forms in which lactate dehydrogenase (LDH) levels are significantly higher. A linear relationship is established between levels of LDH and size of clone PNH, represented in Fig.1.
Affiliation: Hematology Service, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.