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Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial.

Armstrong DG, Hanft JR, Driver VR, Smith AP, Lazaro-Martinez JL, Reyzelman AM, Furst GJ, Vayser DJ, Cervantes HL, Snyder RJ, Moore MF, May PE, Nelson JL, Baggs GE, Voss AC, Diabetic Foot Nutrition Study Gro - Diabet. Med. (2014)

Bottom Line: However, in subjects with an albumin level of ≤ 40 g/l and/or an ankle-brachial index of < 1.0, a significantly greater proportion of subjects in the arginine, glutamine and β-hydroxy-β-methylbutyrate group healed at week 16 compared with control subjects (P = 0.03 and 0.008, respectively).Those with low albumin or decreased limb perfusion in the supplementation group were 1.70 (95% CI 1.04-2.79) and 1.66 (95% CI 1.15-2.38) times more likely to heal.Further investigation involving arginine, glutamine and β-hydroxy-β-methylbutyrate in these high-risk subgroups might prove clinically valuable.

View Article: PubMed Central - PubMed

Affiliation: Southern Arizona Limb Salvage Alliance (SALSA), Department of Surgery, University of Arizona College of Medicine, Tucson, AZ.

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Related in: MedlinePlus

Median wound area (cm2) by week; arginine, glutamine and β-hydroxy-β-methylbutyrate supplementation (▪) (n = 129) and Control (○) (n = 141).
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fig03: Median wound area (cm2) by week; arginine, glutamine and β-hydroxy-β-methylbutyrate supplementation (▪) (n = 129) and Control (○) (n = 141).

Mentions: There were no statistically significant differences in the primary outcomes (proportion of subjects with total wound closure at 16 weeks; Fig.2) and time to complete healing (data not shown). There was no statistical difference between groups in wound area (Fig.3) and other secondary outcomes (Table2).


Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial.

Armstrong DG, Hanft JR, Driver VR, Smith AP, Lazaro-Martinez JL, Reyzelman AM, Furst GJ, Vayser DJ, Cervantes HL, Snyder RJ, Moore MF, May PE, Nelson JL, Baggs GE, Voss AC, Diabetic Foot Nutrition Study Gro - Diabet. Med. (2014)

Median wound area (cm2) by week; arginine, glutamine and β-hydroxy-β-methylbutyrate supplementation (▪) (n = 129) and Control (○) (n = 141).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232867&req=5

fig03: Median wound area (cm2) by week; arginine, glutamine and β-hydroxy-β-methylbutyrate supplementation (▪) (n = 129) and Control (○) (n = 141).
Mentions: There were no statistically significant differences in the primary outcomes (proportion of subjects with total wound closure at 16 weeks; Fig.2) and time to complete healing (data not shown). There was no statistical difference between groups in wound area (Fig.3) and other secondary outcomes (Table2).

Bottom Line: However, in subjects with an albumin level of ≤ 40 g/l and/or an ankle-brachial index of < 1.0, a significantly greater proportion of subjects in the arginine, glutamine and β-hydroxy-β-methylbutyrate group healed at week 16 compared with control subjects (P = 0.03 and 0.008, respectively).Those with low albumin or decreased limb perfusion in the supplementation group were 1.70 (95% CI 1.04-2.79) and 1.66 (95% CI 1.15-2.38) times more likely to heal.Further investigation involving arginine, glutamine and β-hydroxy-β-methylbutyrate in these high-risk subgroups might prove clinically valuable.

View Article: PubMed Central - PubMed

Affiliation: Southern Arizona Limb Salvage Alliance (SALSA), Department of Surgery, University of Arizona College of Medicine, Tucson, AZ.

Show MeSH
Related in: MedlinePlus