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Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial.

Staevska M, Gugutkova M, Lazarova C, Kralimarkova T, Dimitrov V, Zuberbier T, Church MK, Popov TA - Br. J. Dermatol. (2014)

Bottom Line: But is this belief well founded?Both treatments significantly decreased UAS, night-time sleep disturbances and CU-Q2 oL scores (P < 0·001) without significant differences between the two.Compared with baseline, daytime somnolence was significantly reduced by levocetirizine monotherapy (P = 0·006) but not by levocetirizine plus hydroxyzine (P = 0·218).

View Article: PubMed Central - PubMed

Affiliation: Clinical Centre of Allergology, Medical University Sofia, Sofia, Bulgaria.

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Related in: MedlinePlus

Visual analogue scale (VAS) scores for (a) night-time sleep disturbance and (b) daytime sedation at the start of the study (baseline) and after 5 days of treatment with levocetirizine 15 mg daily + hydroxyzine 50 mg at night (Levo + Hydroxy) or levocetirizine daily 20 mg alone (Levo Monotherapy). Horizontal bars indicate median values. Significant differences between treatments were calculated by Wilcoxon’s nonparametric test for paired data. NS, not significant.
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fig04: Visual analogue scale (VAS) scores for (a) night-time sleep disturbance and (b) daytime sedation at the start of the study (baseline) and after 5 days of treatment with levocetirizine 15 mg daily + hydroxyzine 50 mg at night (Levo + Hydroxy) or levocetirizine daily 20 mg alone (Levo Monotherapy). Horizontal bars indicate median values. Significant differences between treatments were calculated by Wilcoxon’s nonparametric test for paired data. NS, not significant.

Mentions: There were highly significant reductions in night-time sleep disturbances (Fig. 4a), with the median baseline VAS of 71 (21·75–78·5) being reduced to 10 (0–25·25) (P = 0·001) by levocetirizine plus hydroxyzine and 17 (0–24·75) (P = 0·002) by levocetirizine monotherapy. There was no significant difference between treatments (P = 0·868).


Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial.

Staevska M, Gugutkova M, Lazarova C, Kralimarkova T, Dimitrov V, Zuberbier T, Church MK, Popov TA - Br. J. Dermatol. (2014)

Visual analogue scale (VAS) scores for (a) night-time sleep disturbance and (b) daytime sedation at the start of the study (baseline) and after 5 days of treatment with levocetirizine 15 mg daily + hydroxyzine 50 mg at night (Levo + Hydroxy) or levocetirizine daily 20 mg alone (Levo Monotherapy). Horizontal bars indicate median values. Significant differences between treatments were calculated by Wilcoxon’s nonparametric test for paired data. NS, not significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232862&req=5

fig04: Visual analogue scale (VAS) scores for (a) night-time sleep disturbance and (b) daytime sedation at the start of the study (baseline) and after 5 days of treatment with levocetirizine 15 mg daily + hydroxyzine 50 mg at night (Levo + Hydroxy) or levocetirizine daily 20 mg alone (Levo Monotherapy). Horizontal bars indicate median values. Significant differences between treatments were calculated by Wilcoxon’s nonparametric test for paired data. NS, not significant.
Mentions: There were highly significant reductions in night-time sleep disturbances (Fig. 4a), with the median baseline VAS of 71 (21·75–78·5) being reduced to 10 (0–25·25) (P = 0·001) by levocetirizine plus hydroxyzine and 17 (0–24·75) (P = 0·002) by levocetirizine monotherapy. There was no significant difference between treatments (P = 0·868).

Bottom Line: But is this belief well founded?Both treatments significantly decreased UAS, night-time sleep disturbances and CU-Q2 oL scores (P < 0·001) without significant differences between the two.Compared with baseline, daytime somnolence was significantly reduced by levocetirizine monotherapy (P = 0·006) but not by levocetirizine plus hydroxyzine (P = 0·218).

View Article: PubMed Central - PubMed

Affiliation: Clinical Centre of Allergology, Medical University Sofia, Sofia, Bulgaria.

Show MeSH
Related in: MedlinePlus