Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial.
Bottom Line: But is this belief well founded?Both treatments significantly decreased UAS, night-time sleep disturbances and CU-Q2 oL scores (P < 0·001) without significant differences between the two.Compared with baseline, daytime somnolence was significantly reduced by levocetirizine monotherapy (P = 0·006) but not by levocetirizine plus hydroxyzine (P = 0·218).
Affiliation: Clinical Centre of Allergology, Medical University Sofia, Sofia, Bulgaria.Show MeSH
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Mentions: There were highly significant reductions in night-time sleep disturbances (Fig. 4a), with the median baseline VAS of 71 (21·75–78·5) being reduced to 10 (0–25·25) (P = 0·001) by levocetirizine plus hydroxyzine and 17 (0–24·75) (P = 0·002) by levocetirizine monotherapy. There was no significant difference between treatments (P = 0·868).
Affiliation: Clinical Centre of Allergology, Medical University Sofia, Sofia, Bulgaria.