Differential responsiveness of distinct retinal domains to Atoh7.
Bottom Line: Atoh7 loss of function results in a massive reduction or even a total loss of RGCs.Photoreceptors were largely absent and the Müller glia cell number was reduced significantly.The majority of cells in this domain were ganglion cells and the abnormal development of this area affected the closure of the optic fissure resulting in coloboma.
Affiliation: Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School (HBIGS), Heidelberg, Germany.Show MeSH
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Mentions: As described above the dorsal retinal domain appeared to be largely normal with correct layering. To further investigate a potentially subtle phenotype with respect to retinal differentiation we quantified cells in the distinct layers of the dorsal retina (GCL: ganglion cells, INL: amacrine cells, horizontal cells, bipolar cells and Müller glia cells and ONL: photoreceptor cells) of rx2::atoh7 hatchlings and controls (Fig. 4).
Affiliation: Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School (HBIGS), Heidelberg, Germany.