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Differential responsiveness of distinct retinal domains to Atoh7.

Sinn R, Peravali R, Heermann S, Wittbrodt J - Mech. Dev. (2014)

Bottom Line: Atoh7 loss of function results in a massive reduction or even a total loss of RGCs.Photoreceptors were largely absent and the Müller glia cell number was reduced significantly.The majority of cells in this domain were ganglion cells and the abnormal development of this area affected the closure of the optic fissure resulting in coloboma.

View Article: PubMed Central - PubMed

Affiliation: Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School (HBIGS), Heidelberg, Germany.

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Altered optic nerve head morphology in rx2::atoh7 hatchlings. (A–F) flat mounted retinae, 5 μm maximum projections, viewed from the RPE, acetylated tubulin (acet. Tub., grey), to visualize neuronal processes, nuclear stain (DAPI, blue); scale bar 20 μm. (A–C) regular optic nerve head formation (arrowhead) with differentiated photoreceptors (D–F) altered optic nerve head morphology (arrowhead) and defects in ventral retinal differentiation.
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f0055: Altered optic nerve head morphology in rx2::atoh7 hatchlings. (A–F) flat mounted retinae, 5 μm maximum projections, viewed from the RPE, acetylated tubulin (acet. Tub., grey), to visualize neuronal processes, nuclear stain (DAPI, blue); scale bar 20 μm. (A–C) regular optic nerve head formation (arrowhead) with differentiated photoreceptors (D–F) altered optic nerve head morphology (arrowhead) and defects in ventral retinal differentiation.


Differential responsiveness of distinct retinal domains to Atoh7.

Sinn R, Peravali R, Heermann S, Wittbrodt J - Mech. Dev. (2014)

Altered optic nerve head morphology in rx2::atoh7 hatchlings. (A–F) flat mounted retinae, 5 μm maximum projections, viewed from the RPE, acetylated tubulin (acet. Tub., grey), to visualize neuronal processes, nuclear stain (DAPI, blue); scale bar 20 μm. (A–C) regular optic nerve head formation (arrowhead) with differentiated photoreceptors (D–F) altered optic nerve head morphology (arrowhead) and defects in ventral retinal differentiation.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232737&req=5

f0055: Altered optic nerve head morphology in rx2::atoh7 hatchlings. (A–F) flat mounted retinae, 5 μm maximum projections, viewed from the RPE, acetylated tubulin (acet. Tub., grey), to visualize neuronal processes, nuclear stain (DAPI, blue); scale bar 20 μm. (A–C) regular optic nerve head formation (arrowhead) with differentiated photoreceptors (D–F) altered optic nerve head morphology (arrowhead) and defects in ventral retinal differentiation.
Bottom Line: Atoh7 loss of function results in a massive reduction or even a total loss of RGCs.Photoreceptors were largely absent and the Müller glia cell number was reduced significantly.The majority of cells in this domain were ganglion cells and the abnormal development of this area affected the closure of the optic fissure resulting in coloboma.

View Article: PubMed Central - PubMed

Affiliation: Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School (HBIGS), Heidelberg, Germany.

Show MeSH
Related in: MedlinePlus