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Differential responsiveness of distinct retinal domains to Atoh7.

Sinn R, Peravali R, Heermann S, Wittbrodt J - Mech. Dev. (2014)

Bottom Line: Atoh7 loss of function results in a massive reduction or even a total loss of RGCs.Photoreceptors were largely absent and the Müller glia cell number was reduced significantly.The majority of cells in this domain were ganglion cells and the abnormal development of this area affected the closure of the optic fissure resulting in coloboma.

View Article: PubMed Central - PubMed

Affiliation: Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School (HBIGS), Heidelberg, Germany.

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Physiological onset of atoh7 expression in the central retina. (A and B) Detected with the atoh7::GFP reporter; atoh7 driven GFP (green), anti-rx2 immunohistochemistry (magenta) with DAPI nuclear counter-labeling (blue), scalebar = 20 μm, note the central onset of atoh7 driven GFP in controls at stage 26. In the periphery no GFP is detectable.
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f0045: Physiological onset of atoh7 expression in the central retina. (A and B) Detected with the atoh7::GFP reporter; atoh7 driven GFP (green), anti-rx2 immunohistochemistry (magenta) with DAPI nuclear counter-labeling (blue), scalebar = 20 μm, note the central onset of atoh7 driven GFP in controls at stage 26. In the periphery no GFP is detectable.


Differential responsiveness of distinct retinal domains to Atoh7.

Sinn R, Peravali R, Heermann S, Wittbrodt J - Mech. Dev. (2014)

Physiological onset of atoh7 expression in the central retina. (A and B) Detected with the atoh7::GFP reporter; atoh7 driven GFP (green), anti-rx2 immunohistochemistry (magenta) with DAPI nuclear counter-labeling (blue), scalebar = 20 μm, note the central onset of atoh7 driven GFP in controls at stage 26. In the periphery no GFP is detectable.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4232737&req=5

f0045: Physiological onset of atoh7 expression in the central retina. (A and B) Detected with the atoh7::GFP reporter; atoh7 driven GFP (green), anti-rx2 immunohistochemistry (magenta) with DAPI nuclear counter-labeling (blue), scalebar = 20 μm, note the central onset of atoh7 driven GFP in controls at stage 26. In the periphery no GFP is detectable.
Bottom Line: Atoh7 loss of function results in a massive reduction or even a total loss of RGCs.Photoreceptors were largely absent and the Müller glia cell number was reduced significantly.The majority of cells in this domain were ganglion cells and the abnormal development of this area affected the closure of the optic fissure resulting in coloboma.

View Article: PubMed Central - PubMed

Affiliation: Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School (HBIGS), Heidelberg, Germany.

Show MeSH
Related in: MedlinePlus