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Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan.

Wu TJ, Wu CF, Lee YL, Hsiue TR, Guo YL - Respir. Res. (2014)

Bottom Line: The participants were schoolchildren's parents recruited from 94 elementary and middle schools in 2004.Highest incidences occurred at ages 0-12 and 36-40 years.Participants with late-onset asthma (onset age >12 years) comprised a large portion of adult current asthmatics.

View Article: PubMed Central - PubMed

Affiliation: Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan. docdocwu@gmail.com.

ABSTRACT

Background: In western countries, late-onset asthmatics are more severe than early-onset asthmatics in clinic-based studies. However, whether asthma occurrence rates were higher in late ages than in younger ages was inconclusive. This information is essentially lacking in Asian population.

Methods: The participants were schoolchildren's parents recruited from 94 elementary and middle schools in 2004. A cross-sectional self-administered questionnaire was sent through the children to their parents to survey their respiratory health. We investigated typical asthma symptoms occurring at different ages and subsequent remission or relapse after the first asthma event. Person-years of the participants from birth to the time of survey were used as the denominator.

Results: Among the 25,377 participants consisting of 949,807 total person-years, 860 reported ever having asthma. Highest incidences occurred at ages 0-12 and 36-40 years. The incidence of asthma was higher in males before puberty, and higher in females after puberty, with overall incidences 1.00 and 0.77 per 1000 person-years for females and males, respectively. Participants with late-onset asthma (onset age >12 years) comprised a large portion of adult current asthmatics. More than 52% of persistence or relapse was observed in early-onset asthma (onset age ≤12 years). The younger birth cohort had a more prominent later peak of asthma incidence than the older one.

Conclusions: In Asian population, asthma occurrence showed a U-shape age distribution with a prominent second peak in the thirties. A high proportion of early-onset asthma relapsed and most of late-onset asthma persisted or relapsed in adulthood.

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Related in: MedlinePlus

Incidence of asthma onset by age group, categorized by current outcomes, namely, complete remission, relapse and persistence. Rates were adjusted for birth cohort and sex by using Poisson regression model. Among 860 cases, 29 of them missed the responses to asthma outcomes.
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Fig4: Incidence of asthma onset by age group, categorized by current outcomes, namely, complete remission, relapse and persistence. Rates were adjusted for birth cohort and sex by using Poisson regression model. Among 860 cases, 29 of them missed the responses to asthma outcomes.

Mentions: The proportions of complete remission were similar among different onset age groups. The highest proportion of persistence occurred at the onset age group of 36–40 years. In contrast, the highest proportion of relapse occurred at the onset age group of 16–18 years (Table 2). In sum, participants with later onset of asthma tended to have active asthma in adulthood; among those with active asthma, a similar bimodal pattern of onset was observed (Figure 4).Table 2


Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan.

Wu TJ, Wu CF, Lee YL, Hsiue TR, Guo YL - Respir. Res. (2014)

Incidence of asthma onset by age group, categorized by current outcomes, namely, complete remission, relapse and persistence. Rates were adjusted for birth cohort and sex by using Poisson regression model. Among 860 cases, 29 of them missed the responses to asthma outcomes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4232728&req=5

Fig4: Incidence of asthma onset by age group, categorized by current outcomes, namely, complete remission, relapse and persistence. Rates were adjusted for birth cohort and sex by using Poisson regression model. Among 860 cases, 29 of them missed the responses to asthma outcomes.
Mentions: The proportions of complete remission were similar among different onset age groups. The highest proportion of persistence occurred at the onset age group of 36–40 years. In contrast, the highest proportion of relapse occurred at the onset age group of 16–18 years (Table 2). In sum, participants with later onset of asthma tended to have active asthma in adulthood; among those with active asthma, a similar bimodal pattern of onset was observed (Figure 4).Table 2

Bottom Line: The participants were schoolchildren's parents recruited from 94 elementary and middle schools in 2004.Highest incidences occurred at ages 0-12 and 36-40 years.Participants with late-onset asthma (onset age >12 years) comprised a large portion of adult current asthmatics.

View Article: PubMed Central - PubMed

Affiliation: Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan. docdocwu@gmail.com.

ABSTRACT

Background: In western countries, late-onset asthmatics are more severe than early-onset asthmatics in clinic-based studies. However, whether asthma occurrence rates were higher in late ages than in younger ages was inconclusive. This information is essentially lacking in Asian population.

Methods: The participants were schoolchildren's parents recruited from 94 elementary and middle schools in 2004. A cross-sectional self-administered questionnaire was sent through the children to their parents to survey their respiratory health. We investigated typical asthma symptoms occurring at different ages and subsequent remission or relapse after the first asthma event. Person-years of the participants from birth to the time of survey were used as the denominator.

Results: Among the 25,377 participants consisting of 949,807 total person-years, 860 reported ever having asthma. Highest incidences occurred at ages 0-12 and 36-40 years. The incidence of asthma was higher in males before puberty, and higher in females after puberty, with overall incidences 1.00 and 0.77 per 1000 person-years for females and males, respectively. Participants with late-onset asthma (onset age >12 years) comprised a large portion of adult current asthmatics. More than 52% of persistence or relapse was observed in early-onset asthma (onset age ≤12 years). The younger birth cohort had a more prominent later peak of asthma incidence than the older one.

Conclusions: In Asian population, asthma occurrence showed a U-shape age distribution with a prominent second peak in the thirties. A high proportion of early-onset asthma relapsed and most of late-onset asthma persisted or relapsed in adulthood.

Show MeSH
Related in: MedlinePlus