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Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study.

Liang J, Teng F, Liu X, Zou C, Wang Y, Dou L, Sun Z, Qi L - Diabetol Metab Syndr (2014)

Bottom Line: The study samples were from a community-based health examination survey in central China.A total of 2588 apparently healthy Chinese men and women were included.Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.

ABSTRACT

Objectives: Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors.

Methods: The study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included.

Results: Plasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level.

Conclusions: Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.

No MeSH data available.


Related in: MedlinePlus

Synergistic effects of SUA, TG and NC on insulin resistance.
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Fig1: Synergistic effects of SUA, TG and NC on insulin resistance.

Mentions: We further tested the interactions between NC (in quintiles) and these metabolic risk factors, and found significant interactions for TG and UA (both in tertiles) in relation to HOMA-IR (all the P for interaction = 0.001). Figure 1 shows the joint effects of NC and UA, as well as NC and TG in relation to HOMA-IR. For both UA and TG, we found that the associations between NC and HOMA-IR were more evident among those with higher levels of these markers.Figure 1


Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study.

Liang J, Teng F, Liu X, Zou C, Wang Y, Dou L, Sun Z, Qi L - Diabetol Metab Syndr (2014)

Synergistic effects of SUA, TG and NC on insulin resistance.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4232709&req=5

Fig1: Synergistic effects of SUA, TG and NC on insulin resistance.
Mentions: We further tested the interactions between NC (in quintiles) and these metabolic risk factors, and found significant interactions for TG and UA (both in tertiles) in relation to HOMA-IR (all the P for interaction = 0.001). Figure 1 shows the joint effects of NC and UA, as well as NC and TG in relation to HOMA-IR. For both UA and TG, we found that the associations between NC and HOMA-IR were more evident among those with higher levels of these markers.Figure 1

Bottom Line: The study samples were from a community-based health examination survey in central China.A total of 2588 apparently healthy Chinese men and women were included.Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.

ABSTRACT

Objectives: Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors.

Methods: The study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included.

Results: Plasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level.

Conclusions: Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.

No MeSH data available.


Related in: MedlinePlus