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Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats.

Xu J, Ma C, Han L, Gao H, Zhou Q, Yang M, Chen C, Deng Q, Huang Q, Huang F - Lipids Health Dis (2014)

Bottom Line: Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation.Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.

View Article: PubMed Central - PubMed

Affiliation: Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P,R, China. fhhuang@foxmail.com.

ABSTRACT

Background: Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet.

Methods: Rats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation.

Results: Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.

Conclusions: These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.

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Related in: MedlinePlus

Effects of optimized rapeseed oils on antioxidant enzymes (SOD, CAT and GPx) activities, GSH and TBARS contents in plasma of rats fed a high-fat diet. RRO: the refined rapeseed oil group; CP: cold pressing rapeseed oil group; DCP: dehulling-cold pressing rapeseed oil group; MPCP: microwave pretreatment-cold pressing rapeseed oil group. Bars represent the mean ± SEM from 10 animals in each group. *p <0.05 and **p <0.01 compared to the RRO group.
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Fig2: Effects of optimized rapeseed oils on antioxidant enzymes (SOD, CAT and GPx) activities, GSH and TBARS contents in plasma of rats fed a high-fat diet. RRO: the refined rapeseed oil group; CP: cold pressing rapeseed oil group; DCP: dehulling-cold pressing rapeseed oil group; MPCP: microwave pretreatment-cold pressing rapeseed oil group. Bars represent the mean ± SEM from 10 animals in each group. *p <0.05 and **p <0.01 compared to the RRO group.

Mentions: As shown in Figure 2, there were no significant differences in plasma SOD activities among various rapeseed oil groups (p >0.05). Animals in CP, DCP and MPCP groups displayed significantly higher GPx activities (p <0.05, 0.05 and 0.01, respectively) and rats in DCP and MPCP groups had marked enhancement of CAT activities (p <0.05 and 0.01, respectively) when compared with their counterparts in RRO group. Besides, plasma GSH levels were also found to be elevated in CP and MPCP groups as compared to that in RRO group (p <0.05 and 0.01, respectively). When plasma TBARS were evaluated as the marker of lipid peroxidation, animals in MPCP group revealed markedly lower TBARS levels than that in RRO group (p <0.01).Figure 2


Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats.

Xu J, Ma C, Han L, Gao H, Zhou Q, Yang M, Chen C, Deng Q, Huang Q, Huang F - Lipids Health Dis (2014)

Effects of optimized rapeseed oils on antioxidant enzymes (SOD, CAT and GPx) activities, GSH and TBARS contents in plasma of rats fed a high-fat diet. RRO: the refined rapeseed oil group; CP: cold pressing rapeseed oil group; DCP: dehulling-cold pressing rapeseed oil group; MPCP: microwave pretreatment-cold pressing rapeseed oil group. Bars represent the mean ± SEM from 10 animals in each group. *p <0.05 and **p <0.01 compared to the RRO group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4232689&req=5

Fig2: Effects of optimized rapeseed oils on antioxidant enzymes (SOD, CAT and GPx) activities, GSH and TBARS contents in plasma of rats fed a high-fat diet. RRO: the refined rapeseed oil group; CP: cold pressing rapeseed oil group; DCP: dehulling-cold pressing rapeseed oil group; MPCP: microwave pretreatment-cold pressing rapeseed oil group. Bars represent the mean ± SEM from 10 animals in each group. *p <0.05 and **p <0.01 compared to the RRO group.
Mentions: As shown in Figure 2, there were no significant differences in plasma SOD activities among various rapeseed oil groups (p >0.05). Animals in CP, DCP and MPCP groups displayed significantly higher GPx activities (p <0.05, 0.05 and 0.01, respectively) and rats in DCP and MPCP groups had marked enhancement of CAT activities (p <0.05 and 0.01, respectively) when compared with their counterparts in RRO group. Besides, plasma GSH levels were also found to be elevated in CP and MPCP groups as compared to that in RRO group (p <0.05 and 0.01, respectively). When plasma TBARS were evaluated as the marker of lipid peroxidation, animals in MPCP group revealed markedly lower TBARS levels than that in RRO group (p <0.01).Figure 2

Bottom Line: Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation.Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.

View Article: PubMed Central - PubMed

Affiliation: Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P,R, China. fhhuang@foxmail.com.

ABSTRACT

Background: Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet.

Methods: Rats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation.

Results: Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.

Conclusions: These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.

Show MeSH
Related in: MedlinePlus