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Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis.

Mattar MA, Gualano B, Perandini LA, Shinjo SK, Lima FR, Sá-Pinto AL, Roschel H - Arthritis Res. Ther. (2014)

Bottom Line: Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05).Importantly, no clinical evidence or any other self-reported adverse event were found.We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).

Methods: In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.

Results: The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.

Conclusions: We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.

Trial registration: Clinicaltrials.gov NCT01501019. Registered November 29, 2011.

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Related in: MedlinePlus

Quadriceps cross-sectional area (CSA) at baseline (PRE) and after 12 weeks of intervention (POST). *P <0.05 when compared with baseline assessments.
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Fig3: Quadriceps cross-sectional area (CSA) at baseline (PRE) and after 12 weeks of intervention (POST). *P <0.05 when compared with baseline assessments.

Mentions: One patient missed the follow-up analysis for quadriceps CSA, therefore, our data shows results from 12 patients. The quadriceps CSA was significantly increased after the BFR training program (4.57%; ES 0.21; P =0.01). Importantly, 10 out of the 12 patients analyzed showed improvements in CSA above that of the CV of the measurement after the intervention. Figure 3 shows the quadriceps CSA data.Figure 3


Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis.

Mattar MA, Gualano B, Perandini LA, Shinjo SK, Lima FR, Sá-Pinto AL, Roschel H - Arthritis Res. Ther. (2014)

Quadriceps cross-sectional area (CSA) at baseline (PRE) and after 12 weeks of intervention (POST). *P <0.05 when compared with baseline assessments.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4232679&req=5

Fig3: Quadriceps cross-sectional area (CSA) at baseline (PRE) and after 12 weeks of intervention (POST). *P <0.05 when compared with baseline assessments.
Mentions: One patient missed the follow-up analysis for quadriceps CSA, therefore, our data shows results from 12 patients. The quadriceps CSA was significantly increased after the BFR training program (4.57%; ES 0.21; P =0.01). Importantly, 10 out of the 12 patients analyzed showed improvements in CSA above that of the CV of the measurement after the intervention. Figure 3 shows the quadriceps CSA data.Figure 3

Bottom Line: Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05).Importantly, no clinical evidence or any other self-reported adverse event were found.We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).

Methods: In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.

Results: The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.

Conclusions: We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.

Trial registration: Clinicaltrials.gov NCT01501019. Registered November 29, 2011.

Show MeSH
Related in: MedlinePlus