Limits...
MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis.

Wang W, Li J, Zhu W, Gao C, Jiang R, Li W, Hu Q, Zhang B - BMC Cancer (2014)

Bottom Line: MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma.The patients' clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association.A random-effects model was adopted, and then, meta-regression and subgroup analyses were performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Zhongshan II Road, Guangzhou 510080, PR China. huqsh@mail.sysu.edu.cn.

ABSTRACT

Background: MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The present meta-analysis summarises and analyses the associations between miR-21 status and overall survival (OS) in a variety of tumours.

Methods: Eligible published studies were identified by searching the PubMed and Chinese Biomedicine databases. The patients' clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association. A random-effects model was adopted, and then, meta-regression and subgroup analyses were performed. In addition, an analysis of publication bias was also conducted.

Results: Twenty-seven eligible articles (including 31 studies) were identified that included survival data for 3273 patients. The pooled HR suggested that high miR-21 was clearly related to worse overall survival (HR = 2.27, 95% CI: 1.81-2.86), with a heterogeneity measure index of I2 = 76.0%, p = 0.001, showing that miR-21 might be a considerable prognostic factor for poor survival in cancer patients.

Conclusions: MiR-21 might be a potentially useful biomarker for predicting cancer prognosis in future clinical applications.

Show MeSH

Related in: MedlinePlus

Meta-analysis of the association between miR-21 expression and prognosis. Meta-analysis of the forest plot showing the association between miR-21 and overall cancer survival. The squares represent the size of the study and are centred on the HR. The whiskers represent the 95% CIs. A random effects (RE) model was used, and the x-axis shows the Hazard ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4232634&req=5

Fig2: Meta-analysis of the association between miR-21 expression and prognosis. Meta-analysis of the forest plot showing the association between miR-21 and overall cancer survival. The squares represent the size of the study and are centred on the HR. The whiskers represent the 95% CIs. A random effects (RE) model was used, and the x-axis shows the Hazard ratio.

Mentions: REMARK was used a guideline rather than a scoring scale, so the assessment was a qualitative process rather than a quantitative one (Additional file 2: Table S2). Instead of grading every published report and ranking their quality as "high" or "low", we carried out an assessment emphasising the analysis and presentation of the studies to prevent the inclusion of inferior data which would influence the accuracy of the meta-analysis. Two studies were eliminated during this procedure due to their small sample size and poor quality of data [12, 59]. In addition, when using the random-effects model due to the significant heterogeneity of the studies, dismal survival outcomes were observed for tumour patients with miR-21 overexpression. The pooled HRs and CIs were 2.27(1.81-2.86), with I2 values of 76.0%, and FigureĀ 2 shows the results of the forest plot explained above.Figure 2


MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis.

Wang W, Li J, Zhu W, Gao C, Jiang R, Li W, Hu Q, Zhang B - BMC Cancer (2014)

Meta-analysis of the association between miR-21 expression and prognosis. Meta-analysis of the forest plot showing the association between miR-21 and overall cancer survival. The squares represent the size of the study and are centred on the HR. The whiskers represent the 95% CIs. A random effects (RE) model was used, and the x-axis shows the Hazard ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4232634&req=5

Fig2: Meta-analysis of the association between miR-21 expression and prognosis. Meta-analysis of the forest plot showing the association between miR-21 and overall cancer survival. The squares represent the size of the study and are centred on the HR. The whiskers represent the 95% CIs. A random effects (RE) model was used, and the x-axis shows the Hazard ratio.
Mentions: REMARK was used a guideline rather than a scoring scale, so the assessment was a qualitative process rather than a quantitative one (Additional file 2: Table S2). Instead of grading every published report and ranking their quality as "high" or "low", we carried out an assessment emphasising the analysis and presentation of the studies to prevent the inclusion of inferior data which would influence the accuracy of the meta-analysis. Two studies were eliminated during this procedure due to their small sample size and poor quality of data [12, 59]. In addition, when using the random-effects model due to the significant heterogeneity of the studies, dismal survival outcomes were observed for tumour patients with miR-21 overexpression. The pooled HRs and CIs were 2.27(1.81-2.86), with I2 values of 76.0%, and FigureĀ 2 shows the results of the forest plot explained above.Figure 2

Bottom Line: MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma.The patients' clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association.A random-effects model was adopted, and then, meta-regression and subgroup analyses were performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Zhongshan II Road, Guangzhou 510080, PR China. huqsh@mail.sysu.edu.cn.

ABSTRACT

Background: MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The present meta-analysis summarises and analyses the associations between miR-21 status and overall survival (OS) in a variety of tumours.

Methods: Eligible published studies were identified by searching the PubMed and Chinese Biomedicine databases. The patients' clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association. A random-effects model was adopted, and then, meta-regression and subgroup analyses were performed. In addition, an analysis of publication bias was also conducted.

Results: Twenty-seven eligible articles (including 31 studies) were identified that included survival data for 3273 patients. The pooled HR suggested that high miR-21 was clearly related to worse overall survival (HR = 2.27, 95% CI: 1.81-2.86), with a heterogeneity measure index of I2 = 76.0%, p = 0.001, showing that miR-21 might be a considerable prognostic factor for poor survival in cancer patients.

Conclusions: MiR-21 might be a potentially useful biomarker for predicting cancer prognosis in future clinical applications.

Show MeSH
Related in: MedlinePlus