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The relationship between epicardial fat thickness and gestational diabetes mellitus.

Nar G, Inci S, Aksan G, Unal OK, Nar R, Soylu K - Diabetol Metab Syndr (2014)

Bottom Line: EFT was significantly higher in the GDM group (P < 0.001) and was correlated with postprandial glucose, BMI, age, and heart rate in both the groups.Only postprandial glucose and BMI remained significantly associated with EFT after multiple stepwise regression analysis.Echocardiographically measured EFT was significantly higher in the patients with GDM.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, State hospital Aksaray, Aksaray, Turkey.

ABSTRACT

Aim: Gestational diabetes mellitus (GDM) is associated with cardiovascular diseases; however, the relationship between epicardial fat thickness (EFT) and GDM remains unclear. The present study evaluates and compares EFT using transthoracic echocardiography in pregnant women with GDM.

Materials and methods: This cross-sectional study included 129 pregnant women in the third trimester: 65 with GDM (GDM group) and 64 with uncomplicated pregnancies (control group). As defined by the World Health Organization, the diagnosis of GDM was based on an abnormal 2-h oral glucose tolerance test (OGTT) results. We used echocardiography to measure EFT in blood samples for all the participants.

Results: The postprandial blood glucose level was significantly higher in the GDM group than in the control group (P < 0.001). There were no significant differences in BMI, heart rate, systolic and diastolic blood pressure or lipid parameters between the groups. In the GDM group, isovolumic relaxation time (IVRT) parameters were significantly higher than in the control group. EFT was significantly higher in the GDM group (P < 0.001) and was correlated with postprandial glucose, BMI, age, and heart rate in both the groups. Only postprandial glucose and BMI remained significantly associated with EFT after multiple stepwise regression analysis.

Conclusion: Echocardiographically measured EFT was significantly higher in the patients with GDM. The findings show that EFT was strongly correlated with postprandial glucose.

No MeSH data available.


Related in: MedlinePlus

The correlation analysis of BMI levels and epicardial fat thickness in both the groups.
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Fig2: The correlation analysis of BMI levels and epicardial fat thickness in both the groups.

Mentions: Pearson’s correlation analysis showed that EFT was positively correlated with the post-prandial glucose level (p < 0.001) and BMI in both the groups (p < 0.01) (Figures 1 and2). Correlation between EFT and other variables are shown in Table 4. Multiple stepwise regression analysis showed that only post prandial glucose (r = 0.627, p < 0.001) and BMI (r = 0.264, p < 0.01) significantly associated with serum EFT.Figure 1


The relationship between epicardial fat thickness and gestational diabetes mellitus.

Nar G, Inci S, Aksan G, Unal OK, Nar R, Soylu K - Diabetol Metab Syndr (2014)

The correlation analysis of BMI levels and epicardial fat thickness in both the groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4232611&req=5

Fig2: The correlation analysis of BMI levels and epicardial fat thickness in both the groups.
Mentions: Pearson’s correlation analysis showed that EFT was positively correlated with the post-prandial glucose level (p < 0.001) and BMI in both the groups (p < 0.01) (Figures 1 and2). Correlation between EFT and other variables are shown in Table 4. Multiple stepwise regression analysis showed that only post prandial glucose (r = 0.627, p < 0.001) and BMI (r = 0.264, p < 0.01) significantly associated with serum EFT.Figure 1

Bottom Line: EFT was significantly higher in the GDM group (P < 0.001) and was correlated with postprandial glucose, BMI, age, and heart rate in both the groups.Only postprandial glucose and BMI remained significantly associated with EFT after multiple stepwise regression analysis.Echocardiographically measured EFT was significantly higher in the patients with GDM.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, State hospital Aksaray, Aksaray, Turkey.

ABSTRACT

Aim: Gestational diabetes mellitus (GDM) is associated with cardiovascular diseases; however, the relationship between epicardial fat thickness (EFT) and GDM remains unclear. The present study evaluates and compares EFT using transthoracic echocardiography in pregnant women with GDM.

Materials and methods: This cross-sectional study included 129 pregnant women in the third trimester: 65 with GDM (GDM group) and 64 with uncomplicated pregnancies (control group). As defined by the World Health Organization, the diagnosis of GDM was based on an abnormal 2-h oral glucose tolerance test (OGTT) results. We used echocardiography to measure EFT in blood samples for all the participants.

Results: The postprandial blood glucose level was significantly higher in the GDM group than in the control group (P < 0.001). There were no significant differences in BMI, heart rate, systolic and diastolic blood pressure or lipid parameters between the groups. In the GDM group, isovolumic relaxation time (IVRT) parameters were significantly higher than in the control group. EFT was significantly higher in the GDM group (P < 0.001) and was correlated with postprandial glucose, BMI, age, and heart rate in both the groups. Only postprandial glucose and BMI remained significantly associated with EFT after multiple stepwise regression analysis.

Conclusion: Echocardiographically measured EFT was significantly higher in the patients with GDM. The findings show that EFT was strongly correlated with postprandial glucose.

No MeSH data available.


Related in: MedlinePlus